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Caspase 3 抗体

CASP3 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal ABM1C12 unconjugated
产品编号 ABIN5027694
发货至: 中国
  • 抗原 See all Caspase 3 (CASP3) 抗体
    Caspase 3 (CASP3)
    适用
    • 273
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    • 31
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    宿主
    • 275
    • 39
    • 4
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    小鼠
    克隆类型
    • 273
    • 48
    单克隆
    标记
    • 153
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    This Caspase 3 antibody is un-conjugated
    应用范围
    • 247
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    • 65
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    • 26
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    Western Blotting (WB), Immunohistochemistry (IHC)
    纯化方法
    Protein G Chromatography
    免疫原
    Full length recombinant Caspase-3 protein was used as the immunogen for this antibody.
    克隆位点
    ABM1C12
    亚型
    IgG1 kappa
    Top Product
    Discover our top product CASP3 Primary Antibody
  • 应用备注
    WB: 2-4 μg/mL, IHC: 5-10 μg/mL
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    PBS containing 0.05 % BSA, PH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • 抗原
    Caspase 3 (CASP3)
    别名
    Caspase-3 (Pro and Active) (CASP3 产品)
    别名
    CPP32 antibody, CPP32B antibody, SCA-1 antibody, A830040C14Rik antibody, AC-3 antibody, Apopain antibody, CC3 antibody, Caspase-3 antibody, Lice antibody, Yama antibody, mldy antibody, xcpp32 antibody, casp3 antibody, zgc:100890 antibody, CASP-3 antibody, caspase-3 antibody, caspase 3 antibody, caspase 3 S homeolog antibody, caspase 3, apoptosis-related cysteine peptidase a antibody, caspase 3, apoptosis-related cysteine peptidase antibody, CASP3 antibody, Casp3 antibody, casp3.S antibody, casp3a antibody
    背景
    Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.
    分子量
    31 kDa
    基因ID
    12367
    UniProt
    P70677
    途径
    Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation
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