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IRF7 抗体 (C-Term)

This anti-IRF7 antibody is a 兔 多克隆 antibody detecting IRF7 in WB, IHC (p) 和 EIA. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN500058
发货至: 中国

Quick Overview for IRF7 抗体 (C-Term) (ABIN500058)

抗原

See all IRF7 抗体
IRF7 (Interferon Regulatory Factor 7 (IRF7))

适用

  • 72
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  • 17
  • 8
  • 3
  • 2
  • 2
  • 1
人, 小鼠, 大鼠

宿主

  • 70
  • 3

克隆类型

  • 58
  • 15
多克隆

标记

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  • 2
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  • 2
  • 2
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  • 1
This IRF7 antibody is un-conjugated

应用范围

  • 51
  • 22
  • 17
  • 14
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  • 6
  • 6
  • 3
  • 3
  • 3
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • 抗原表位

    • 16
    • 16
    • 15
    • 8
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    特异性

    This antibody reacts to IRF7.

    纯化方法

    Affinity chromatography purified via peptide column

    免疫原

    IRF7 antibody was raised against a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7.

    亚型

    IgG
  • 应用备注

    ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store the antibody undiluted at 2-8 °C.
  • Desnues, Macedo, Ordoñez-Rueda, Roussel-Queval, Malissen, Bruhns, Malissen, Alexopoulou: "The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling." in: European journal of immunology, Vol. 46, Issue 12, pp. 2801-2811, (2017) (PubMed).

  • 抗原

    IRF7 (Interferon Regulatory Factor 7 (IRF7))

    别名

    IRF7

    背景

    Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.Synonyms: IRF-7, Interferon regulatory factor 7

    基因ID

    3665

    UniProt

    Q92985

    途径

    TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagy
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