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CHEK2 抗体 (N-Term)

Name: CHEK2 抗体 (N-Term)
SKU: ABIN499619
Availability: OutOfStock

This anti-CHEK2 antibody is a 兔多克隆 antibody detecting CHEK2 in WB, IF 和 EIA. Suitable for 人, 小鼠和大鼠.

Western blot analysis of Chk2 expression in K562 (A), Jurkat (B), and HL-60 (C) whole cell lysates with AP30226PU-N Chk2 antibody at 1 μg /ml. (CHEK2 抗体 (N-Term))

Immunocytochemistry of Chk2 in Jurkat cells with AP30226PU-N Chk2 antibody at 1 μg/ml. (CHEK2 抗体 (N-Term))

2 images

产品编号 ABIN499619

发货至: 中国

Datasheet as PDF

Quick Overview for CHEK2 抗体 (N-Term) (ABIN499619)

抗原

See all CHEK2 抗体

CHEK2 (Checkpoint Kinase 2 (CHEK2))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This CHEK2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Discover our top product CHEK2 Primary Antibody

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N-Term

特异性

Chk2 antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human Chk2.

纯化方法

Affinity chromatography purified via peptide column

免疫原

Human Chk2 (N-Terminus) Peptide

亚型

IgG
anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibody
CHEK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 4B7 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibody
CHEK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 适用: 人, 犬 WB, IHC, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 2H5 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 适用: 人, 犬 WB, IHC, IF, IP, IHC (p), FACS 宿主: 小鼠 Monoclonal 5C4 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) antibody
CHEK2 适用: 人, 猴, 犬 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 10G7 unconjugated

anti-Checkpoint Kinase 2 (CHEK2) (AA 1-220) antibody
CHEK2 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated

应用备注

ELISA. Western Blot: Chk2 antibody can be used for detection of Chk2 at 0.5 to 1 μg/mL. A 60 kDaband can be detected. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

1 mg/mL

缓冲液

PBS containing 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store the antibody undiluted at 2-8 °C.
抗原

CHEK2 (Checkpoint Kinase 2 (CHEK2))

别名

CHK2

背景

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), and PID/MTA2 (6), were recently discovered. The checkpoint kinase Chk2 is the mammalian homologue of yeast Cds1/Rad53. In response to DNA damage, the checkpoint kinase ATM phosphorylates and activates Chk2, which in turn directly phosphorylates and activates p53 (7,8). Chk2 serves as ATM downstream effector to mediate activation of p53. Chk2 also phosphorylates and activates BRCA1, the product of a tumor suppressor gene that is mutated in breast and ovarian cancer (9).Synonyms: CHEK-2, CHEK2, CHK-2, CHK2 checkpoint homolog, Cds1, RAD53, Serine/threonine-protein kinase Chk2

基因ID

11200

NCBI登录号

NP_009125

UniProt

O96017

途径

p53 Pathway, Apoptosis, Cell Division Cycle