Caspase 8 抗体 (C-Term)
Quick Overview for Caspase 8 抗体 (C-Term) (ABIN499573)
抗原
See all Caspase 8 (CASP8) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- Caspase-8 antibody was raised against a 16 amino acid peptide from near the carboxy-terminus of human Caspase-8 isoform A.
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Virus Casp-8 / FLICE / MACH / Mch5 (C-Terminus) Peptide
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亚型
- IgG
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anti-Caspase 8 (CASP8) (AA 411-482) antibody
CASP8 适用: 人, 小鼠, 大鼠, 猴, Pig, 绵羊 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 1-479) antibodyCASP8 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 188-280) antibodyCASP8 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 217-384) antibodyCASP8 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 7-201) antibodyCASP8 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 385-479) antibodyCASP8 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) antibodyCASP8 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 1H11 unconjugated
anti-Caspase 8 (CASP8) (AA 410-449), (N-Term) antibodyCASP8 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) (AA 217-374) antibodyCASP8 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Caspase 8 (CASP8) antibodyCASP8 适用: 小鼠 WB, IHC, ELISA, ICC, FACS 宿主: 大鼠 Monoclonal 3B10 unconjugated
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应用备注
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ELISA. Western Blot: Caspase-8 antibody can be used for the detection of caspase-8 at 0.5 μg/mL. Depending on cell lines or tissues used, either full-length or other cleavage products maybe observed. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store the antibody undiluted at 2-8 °C.
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- Caspase 8 (CASP8)
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别名
- Caspase-8
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背景
- Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens (reviewed in 1 and 2). The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death (reviewed in 3). Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex (4). The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain, subsequent oligomerization promotes procaspase-8 autoactivation (reviewed in 5). FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis (6).Synonyms: Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, CASP-8, CASP8, FADD-homologous ICE/CED-3-like protease, FADD-like ICE, ICE-like apoptotic protease 5, MCH5, MORT1-associated CED-3 homolog
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基因ID
- 841
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NCBI登录号
- NP_001219
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UniProt
- Q14790
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途径
- Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades
抗原
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