-
- 抗原 See all ZC3HC1 抗体
- ZC3HC1 (Zinc Finger, C3HC-Type Containing 1 (ZC3HC1))
-
适用
- 人, 小鼠, 大鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This ZC3HC1 antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 特异性
- This antibody detects endogenous levels of NIPA protein.
- 交叉反应 （详细）
-
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity-Chromatography using epitope-specific immunogen
- Top Product
- Discover our top product ZC3HC1 Primary Antibody
-
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (AA 1-260) antibody
ZC3HC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (C-Term) antibodyZC3HC1 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) antibodyZC3HC1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (AA 1-260) antibodyZC3HC1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (Tyr713) antibodyZC3HC1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (AA 320-369) antibodyZC3HC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Zinc Finger, C3HC-Type Containing 1 (ZC3HC1) (AA 320-369) antibodyZC3HC1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Western blot: 1: 500 - 1: 1000. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
-
- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS pH ~7.2 with 0.05 % Sodium Azide as preservative
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
-
- 抗原
- ZC3HC1 (Zinc Finger, C3HC-Type Containing 1 (ZC3HC1))
- 别名
- ZC3HC1 (ZC3HC1 产品)
- 别名
- 1110054L24Rik antibody, AU018540 antibody, AU019789 antibody, HSPC216 antibody, Nipa antibody, NIPA antibody, RGD1561099 antibody, zinc finger, C3HC type 1 antibody, zinc finger C3HC-type containing 1 antibody, zinc finger, C3HC-type containing 1 antibody, Zc3hc1 antibody, ZC3HC1 antibody
- 背景
- Entry into mitosis is essentially driven by cyclin B1, which is located in the cytoplasm throughout interphase, but accumulates in the nucleus just before mitosis occurs. Nuclear interaction partner of ALK (NIPA) plays a critical role in cyclin B1 regulation. NIPA is normally phosphorylated during G2 and M phases, resulting in an accumulation of cyclin B1. When NIPA sheds its attached phosphate, it binds to SCF to form the SCFNIPA complex, a member of the E3 ubiquitin ligases, which ubiquitinates cyclin B1, thereby targeting it to the proteosome for degradation. Therefore, the accumulation of cyclin B1 is due to the inability of phosphorylated NIPA to bind to the molecule SCF, thereby preventing the degradation of cyclin B1. An absence of NIPA causes cyclin B1 to accumulate abnormally, leading to premature mitotic entry, loss of checkpoint control and genomic instability, which are all associated with cancer. The phosphorylated form of NIPA may also be involved in apoptotic signaling pathways.Synonyms: HSPC216, NIPA, Nuclear-interacting partner of anaplastic lymphoma kinase (ALK), Zinc finger C3HC-type protein 1
- 分子量
- approx. 55 kDa
- 基因ID
- 51530
- NCBI登录号
- NP_057562
- UniProt
- Q86WB0
-
You are here:
