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- 抗原 See all STAM2 抗体
- STAM2 (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2))
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This STAM2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of STAM2 protein.
- 交叉反应 （详细）
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Species reactivity (expected):Mouse.
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product STAM2 Primary Antibody
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anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (AA 416-525) antibody
STAM2 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1A10 unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (AA 376-525) antibodySTAM2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (AA 1-377) antibodySTAM2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (AA 376-525) antibodySTAM2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) antibodySTAM2 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) antibodySTAM2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (AA 1-377) antibodySTAM2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (Internal Region) antibodyVerified STAM2 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (pTyr192) antibodySTAM2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2) (AA 416-525) antibodySTAM2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- STAM2 (Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2 (STAM2))
- 别名
- STAM2 (STAM2 产品)
- 别名
- Hbp antibody, STAM2A antibody, STAM2B antibody, 1200004O12Rik antibody, 5730456G07Rik antibody, BB145015 antibody, stam2 antibody, MGC52950 antibody, zgc:103628 antibody, signal transducing adaptor molecule 2 antibody, signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 antibody, signal transducing adaptor molecule 2 S homeolog antibody, STAM2 antibody, Stam2 antibody, stam2.S antibody, stam2 antibody
- 背景
- Cytokine stimulation of the IL-2 receptor leads to the tyrosine phosphorylation of a number of cellular proteins and to the induction of various transcription factors including c-Fos and c-Myc. The signal transducing adapter molecule, STAM, is speculated to play a role in c-Myc induction by various cytokines. STAM contains an SH3 (Src homology 3) motif as well as an immunoreceptor tyrosine-based activation (ITAM) motif, both of which appear to be required for c-Myc induction in response to IL-2 and GM-CSF. STAM associates with JAK3 and JAK2 via its ITAM region, and it is tyrosine phosphorylated by JAK3 and JAK2 after stimulation with IL-2 and GM-CSF, respectively. STAM2, also known as Hbp, is a protein that is highly related to STAM. Similar to STAM, STAM2 functions downstream of JAK kinases and can be phosphorylated in response to cytokines. Due to alternative splicing events, two isoforms of STAM2 exist, namely STAM2A and STAM2B.Synonyms: HBP, Hrs-binding protein, STAM-2, STAM2A, STAM2B, Signal transducing adapter molecule 2
- 分子量
- approx. 58 kDa
- 基因ID
- 10254
- NCBI登录号
- NP_005834
- UniProt
- O75886
- 途径
- EGFR Signaling Pathway, EGFR Downregulation
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