TRAF1 抗体 (AA 55-83)
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Quick Overview for TRAF1 抗体 (AA 55-83) (ABIN3029144)
抗原
See all TRAF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 55-83
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 55-83 from the human protein was used as the immunogen for this TRAF1 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the TRAF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the TRAF1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- TRAF1 (TNF Receptor-Associated Factor 1 (TRAF1))
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别名
- TRAF1
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背景
- The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV). EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins, this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.
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UniProt
- Q13077
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途径
- NF-kappaB Signaling, Apoptosis, Cell-Cell Junction Organization, Asymmetric Protein Localization
抗原
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