CDKN2A 抗体 (pSer8)
Quick Overview for CDKN2A 抗体 (pSer8) (ABIN3030641)
抗原
See all CDKN2A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer8
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-CDKN2A antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS8 of human CDKN2A.
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亚型
- Ig Fraction
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anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 104-131), (C-Term) antibody
CDKN2A 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB19093 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) antibodyCDKN2A 适用: 人 WB, IF, IHC 宿主: 兔 Monoclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (pSer140) antibodyCDKN2A 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB21280 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 1-30), (N-Term) antibodyCDKN2A 适用: 人 WB 宿主: 兔 Polyclonal RB41435 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 145-176), (Ser152) antibodyCDKN2A 适用: 人 WB 宿主: 兔 Polyclonal RB53347 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (pSer8) antibodyCDKN2A 适用: 人 DB 宿主: 兔 Polyclonal RB41435 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 39-65) antibodyCDKN2A 适用: 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 1-30) antibodyCDKN2A 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A) (AA 39-65) antibodyCDKN2A 适用: 小鼠 WB 宿主: 兔 Polyclonal RB40175 unconjugated
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应用备注
- Titration of the phospho-CDKN2A antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-CDKN2A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
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别名
- CDKN2A
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背景
- This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
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UniProt
- P42771
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途径
- Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagy, Positive Regulation of Response to DNA Damage Stimulus
抗原
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