CDKN2A 抗体 (pSer140)
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- 抗原 See all CDKN2A 抗体
- CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
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抗原表位
- pSer140
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CDKN2A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This p16-INK4A Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S140 of human p16-INK4A.
- 克隆位点
- RB21280
- 亚型
- Ig Fraction
- Top Product
- Discover our top product CDKN2A Primary Antibody
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- 应用备注
- WB: 1:1000. IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation." in: Molecular cancer research : MCR, Vol. 9, Issue 3, pp. 311-9, (2011) (PubMed).
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The atr protein kinase controls UV-dependent upregulation of p16INK4A through inhibition of Skp2-related polyubiquitination/degradation." in: Molecular cancer research : MCR, Vol. 9, Issue 3, pp. 311-9, (2011) (PubMed).
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- 抗原
- CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
- 别名
- p16-INK4A (CDKN2A 产品)
- 别名
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Arf antibody, p16 antibody, MTS1 antibody, INK4A antibody, p19ARF antibody, p16Cdkn2a antibody, ARF antibody, CDK4I antibody, CDKN2 antibody, CMM2 antibody, INK4 antibody, MLM antibody, MTS-1 antibody, P14 antibody, P14ARF antibody, P16 antibody, P16-INK4A antibody, P16INK4 antibody, P16INK4A antibody, P19 antibody, P19ARF antibody, TP16 antibody, ARF-INK4a antibody, INK4a-ARF antibody, Ink4a/Arf antibody, Pctr1 antibody, p16(INK4a) antibody, p16INK4a antibody, p19
antibody, cyclin-dependent kinase inhibitor 2A antibody, cyclin dependent kinase inhibitor 2A antibody, Cdkn2a antibody, LOC100731972 antibody, LOC100340625 antibody, CDKN2A antibody - 背景
- P16-INK4A functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. This protein acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. The gene for this protein is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
- 分子量
- 16533
- NCBI登录号
- NP_000068, NP_001182061, NP_478104
- UniProt
- P42771
- 途径
- Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagy, Positive Regulation of Response to DNA Damage Stimulus
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