Lamin A/C 抗体 (AA 465-498)
Quick Overview for Lamin A/C 抗体 (AA 465-498) (ABIN3031584)
抗原
See all Lamin A/C (LMNA) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 465-498
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纯化方法
- Antigen affinity purified
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免疫原
- This Lamin A/C antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 465-498 amino acids from the Central region of the human protein.
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亚型
- Ig Fraction
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应用备注
- Titration of the Lamin A/C antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:500-1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Lamin A/C antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Lamin A/C (LMNA)
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别名
- Lamin A/C
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背景
- Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.
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UniProt
- P02545
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途径
- Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
抗原
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