MAPK10 抗体 (AA 1-30)
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北京 101111
Quick Overview for MAPK10 抗体 (AA 1-30) (ABIN3031827)
抗原
See all MAPK10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-30
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纯化方法
- Purified
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免疫原
- A portion of amino acids 1-30 from the human protein was used as the immunogen for this JNK3 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the JNK3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the JNK3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- MAPK10 (Mitogen-Activated Protein Kinase 10 (MAPK10))
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别名
- JNK3
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背景
- JNK3 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.
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UniProt
- P53779
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途径
- MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
抗原
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