JNK2 抗体 (AA 349-379)
Our Local Distributor
北京 101111
Quick Overview for JNK2 抗体 (AA 349-379) (ABIN3031838)
抗原
See all JNK2 (MAPK9) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 349-379
-
纯化方法
- Antigen affinity purified
-
免疫原
- A portion of amino acids 349-379 from the human protein was used as the immunogen for this JNK2 antibody.
-
亚型
- Ig Fraction
-
-
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 321-424) antibody
MAPK9 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2F8 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 321-424) antibodyMAPK9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D6 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibodyMAPK9 适用: 人 WB, ELISA, IHC (p), RNAi 宿主: 小鼠 Monoclonal 1C1-3A8 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibodyMAPK9 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 2G3 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 227-382) antibodyMAPK9 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 2F6H11 unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 130-387) antibodyMAPK9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 1-424) antibodyMAPK9 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (pThr183) antibodyMAPK9 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) antibodyMAPK9 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 9 (MAPK9) (AA 349-379), (C-Term) antibodyMAPK9 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2510 unconjugated
-
-
应用备注
- Titration of the JNK2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the JNK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- JNK2 (MAPK9) (Mitogen-Activated Protein Kinase 9 (MAPK9))
-
别名
- JNK2
-
背景
- JNK2 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it. JNK2 is activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. It is inhibited by dual specificity phosphatases, such as DUSP1. The protein has been shown to bind to at least three scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2 and MAPK8IP3/JIP-3/JSAP1. These proteins also bind other components of the JNK signaling pathway
-
UniProt
- P45984
-
途径
- MAPK Pathway, WNT signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins
抗原
-
