FGFR3 抗体 (AA 776-806)
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Quick Overview for FGFR3 抗体 (AA 776-806) (ABIN3030957)
抗原
See all FGFR3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 776-806
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纯化方法
- Purified
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免疫原
- A portion of amino acids 776-806 from the human protein was used as the immunogen for this FGFR3 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the FGFR3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the FGFR3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- FGFR3 (Fibroblast Growth Factor Receptor 3 (FGFR3))
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别名
- FGFR3
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背景
- FGFR3 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia.
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UniProt
- P22607
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Growth Factor Binding
抗原
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