BAX 抗体 (N-Term)
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Quick Overview for BAX 抗体 (N-Term) (ABIN3030141)
抗原
See all BAX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 47-78, N-Term
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原理
- BAX Antibody
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纯化方法
- Antigen affinity
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免疫原
- This BAX antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 47-78 amino acids from the N-terminal region of human BAX.
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亚型
- Ig Fraction
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应用备注
- Titration of the BAX antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the BAX antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- BAX (BCL2-Associated X Protein (BAX))
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别名
- BAX
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背景
- Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.
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UniProt
- Q07812
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途径
- p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
抗原
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