BAD 抗体 (AA 92-127)
Quick Overview for BAD 抗体 (AA 92-127) (ABIN3030135)
抗原
See all BAD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 92-127
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纯化方法
- Purified
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免疫原
- A portion of amino acids 92-127 from the human protein was used as the immunogen for this Bad antibody.
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亚型
- Ig Fraction
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anti-BCL2-Associated Agonist of Cell Death (BAD) (AA 101-204) antibody
BAD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (AA 1-168) antibodyBAD 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (AA 1-168) antibodyBAD 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 1G5B3 unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (AA 69-168) antibodyBAD 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 3H8 unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (pSer136) antibodyBAD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (pSer155) antibodyBAD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (pSer99) antibodyBAD 适用: 人 ELISA, IHC, DB, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (AA 1-168) antibodyBAD 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (AA 53-81) antibodyBAD 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB06939 unconjugated
anti-BCL2-Associated Agonist of Cell Death (BAD) (pSer128) antibodyBAD 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
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应用备注
- Titration of the Bad antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Flow Cytometry: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Bad antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- BAD (BCL2-Associated Agonist of Cell Death (BAD))
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别名
- Bad
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背景
- Apoptosis or programmed cell death is a physiological cellular process characterized by cell shrinkage, membrane blebbing, DNA fragmentation, and release of Cytochrome C from the mitochondria. It is utilized by the organism to get rid of unwanted cells, which is critical for normal development and homeostasis of an organism. Disregulation of normal apoptosis process have been implicated in a variety of diseases, including cancer, autoimmune diseases, viral infections, etc. Programmed cell death occurs through complex cascades of cell signaling in which Bcl-2 family members, among others, play an important role.The Bcl-2 family of proteins regulate apoptosis as well as execute death signals at the mitochondrion. Members of this family include both pro- and anti-apoptotic proteins that hare homology sequences called Bcl-2 Homology domains (BH1-4) which mediate dimmer formation. The BH3 proteins, such as BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region, which is required for their apoptotic function. They may trigger release of death-inducing molecules such as Cytochrome C, Smac, and endonuclease G. Anti-apoptotic family members, including Bcl-2 and Bcl-XL, play inhibitory roles. Bcl-2 family proteins may form homodimers or heterodimers between pro- and anti-apoptotic members, the ratios of which determine the cell fate.
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UniProt
- Q92934
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途径
- MAPK Pathway, PI3K-Akt Signaling, RTK signaling, Apoptosis, Fc-epsilon Receptor Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events
抗原
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