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- 抗原 See all FE65 (APBB1) 抗体
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
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适用
- 小鼠, 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This FE65 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Antigen affinity
- 免疫原
- Amino acids ALSLPLPLHAAHNQLLNAKLQATAVGPKDLRSAMGE of human FE65 were used as the immunogen for the FE65 antibody.
- 亚型
- IgG
- Top Product
- Discover our top product APBB1 Primary Antibody
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anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 21-56), (N-Term) antibody
APBB1 适用: 小鼠, 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 201-300) antibodyAPBB1 适用: 小鼠, 大鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 361-710) antibodyAPBB1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 1-708) antibodyAPBB1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (C-Term) antibodyAPBB1 适用: 小鼠, 人, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) antibodyAPBB1 适用: 大鼠 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (pSer175) antibodyAPBB1 适用: 小鼠 WB, IF (cc), IF (p), ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (C-Term) antibodyVerified APBB1 适用: 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 197-246) antibodyAPBB1 适用: 小鼠, 人, 大鼠, 兔, 犬, Cow, 豚鼠, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1) (AA 359-708) antibodyAPBB1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal dilution of the FE65 antibody should be determined by the researcher.\. Western blot: 0.1-0.5 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
- 限制
- 仅限研究用
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- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the FE65 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- 抗原
- FE65 (APBB1) (Amyloid beta (A4) Precursor Protein-Binding, Family B, Member 1 (Fe65) (APBB1))
- 别名
- FE65 (APBB1 产品)
- 别名
- FE65 antibody, MGC:9072 antibody, RIR antibody, apbb1 antibody, MGC80654 antibody, Fe65 antibody, Rir antibody, amyloid beta precursor protein binding family B member 1 antibody, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) L homeolog antibody, amyloid beta (A4) precursor protein-binding, family B, member 1 antibody, APBB1 antibody, apbb1.L antibody, Apbb1 antibody
- 背景
- APBB1/RIR/FE65 is a transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its trancription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). encoding different isoforms have been described for this gene.
- UniProt
- O00213
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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