TDP2 抗体
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- 抗原 See all TDP2 抗体
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TDP2 antibody is un-conjugated
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应用范围
- Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Protein G affinity chromatography
- 免疫原
- Human recombinant full length protein was used as the immunogen for this TDP2 antibody.
- 克隆位点
- TDP2-1258
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product TDP2 Primary Antibody
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anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibody
TDP2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 1-362) antibodyTDP2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 1-362) antibodyTDP2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D11 unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 246-272), (C-Term) antibodyTDP2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB20005 unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (Middle Region) antibodyTDP2 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 253-281), (C-Term) antibodyTDP2 适用: 人 WB, IF, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibodyTDP2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 154-203) antibodyTDP2 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, Bat, 猴, 斑马鱼 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibodyKO Validated TDP2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibodyGMP Grade TDP2 适用: 人 WB 宿主: 小鼠 Monoclonal 42c unconjugated
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- 应用备注
- The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the TDP2 antibody to be titered up or down for optimal performance.\. FACS: 0.5-1 μg/10^6 cells in 0.1ml,IF: 0.5-1 μg/mL,IHC (FFPE): 0.5-1 μg/mL for 30 min at RT
- 限制
- 仅限研究用
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- 浓度
- 0.2 mg/mL
- 缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store the TDP2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
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- 抗原
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
- 别名
- TDP2 / ETS1 associated protein II (TDP2 产品)
- 别名
- AD022 antibody, EAP2 antibody, EAPII antibody, TTRAP antibody, dJ30M3.3 antibody, hTDP2 antibody, ad022 antibody, eap2 antibody, ttrap antibody, D13Ertd656e antibody, Ttrap antibody, tdp2 antibody, ttrapl antibody, tyrosyl-DNA phosphodiesterase 2 antibody, tyrosyl-DNA phosphodiesterase 2 S homeolog antibody, tyrosyl-DNA phosphodiesterase 2b antibody, TDP2 antibody, tdp2.S antibody, Tdp2 antibody, tdp2b antibody
- 背景
- This mAb recognizes a protein of 41 kDa, which is identified as TDP2, or ETS1 associated protein II. It is a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
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