-
- 抗原 See all TDP2 抗体
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This TDP2 antibody is un-conjugated
-
应用范围
- Western Blotting (WB)
- 产品特性
- EAPII (also called TTRAP, TDP2) originally was identified as an interacting partner of oncogene ETS1, a founding member of ets transcription factor, and the cytoplasmic domain of CD40, a member of the tumor necrosis factor (TNF) receptor family. EAPII significantly represses ETS1 transcriptional activity and the synergistic transactivation by ETS1 and AP-1 or by ETS1 and NFκB. EAPII/TTRAP also inhibits the transcriptional activation of NFB induced by CD40 or phorbol 12-myristate 13-acetate (PMA). Recently this protein was also proven to be the first 5'- tyrosyl-DNA phosphodiesterase. EAPII has been demonstrated to have promiscuous protein associations, broad responsiveness to various extracellular signals, and pleiotropic functions in the development of human diseases including cancer and neurodegenerative disease. Emerging data suggest that EAPII is a multi-functional protein: it repairs enzyme (topoisomerase)-mediated DNA damage by removing phosphotyrosine from DNA adducts, involves in multiple signal transduction pathways such as TNF-TNFR, TGFβ and MAPK, and responsive to immune defense including inflammatory response, viral infection and DNA toxins (chemo or radiation therapy). EAPII predominantly localizes to the nucleus, but based on pathological conditions it also localizes in both cytoplasm and nucleus.
- 纯化方法
- Purified
- 纯度
- >95 %
- 质量等级
- GMP Grade
- 免疫原
- Recombinant full length protein
- 克隆位点
- 42c
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product TDP2 Primary Antibody
-
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibody
TDP2 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 1-362) antibodyTDP2 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 1-362) antibodyTDP2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D11 unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 246-272), (C-Term) antibodyTDP2 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB20005 unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (Middle Region) antibodyTDP2 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 253-281), (C-Term) antibodyTDP2 适用: 人 WB, IF, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibodyTDP2 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) (AA 154-203) antibodyTDP2 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, Bat, 猴, 斑马鱼 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibodyKO Validated TDP2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-tyrosyl-DNA phosphodiesterase 2 (TDP2) antibodyTDP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 69s87 unconjugated
-
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- PBS pH 7.2, 0.1 % (w/v) BSA, 0.09 % (w/v) sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
-
- 抗原
- TDP2 (tyrosyl-DNA phosphodiesterase 2 (TDP2))
- 别名
- EAPII (TDP2 产品)
- 别名
- AD022 antibody, EAP2 antibody, EAPII antibody, TTRAP antibody, dJ30M3.3 antibody, hTDP2 antibody, ad022 antibody, eap2 antibody, ttrap antibody, D13Ertd656e antibody, Ttrap antibody, tdp2 antibody, ttrapl antibody, tyrosyl-DNA phosphodiesterase 2 antibody, tyrosyl-DNA phosphodiesterase 2 S homeolog antibody, tyrosyl-DNA phosphodiesterase 2b antibody, TDP2 antibody, tdp2.S antibody, Tdp2 antibody, tdp2b antibody
- 背景
- EAPII (also called TTRAP, TDP2) originally was identified as an interacting partner of oncogene ETS1, a founding member of ets transcription factor, and the cytoplasmic domain of CD40, a member of the tumor necrosis factor (TNF) receptor family. EAPII significantly represses ETS1 transcriptional activity and the synergistic transactivation by ETS1 and AP-1 or by ETS1 and NFκB. EAPII/TTRAP also inhibits the transcriptional activation of NFB induced by CD40 or phorbol 12-myristate 13-acetate (PMA). Recently this protein was also proven to be the first 5'- tyrosyl-DNA phosphodiesterase. EAPII has been demonstrated to have promiscuous protein associations, broad responsiveness to various extracellular signals, and pleiotropic functions in the development of human diseases including cancer and neurodegenerative disease. Emerging data suggest that EAPII is a multi-functional protein: it repairs enzyme (topoisomerase)-mediated DNA damage by removing phosphotyrosine from DNA adducts, involves in multiple signal transduction pathways such as TNF-TNFR, TGFβ and MAPK, and responsive to immune defense including inflammatory response, viral infection and DNA toxins (chemo or radiation therapy). EAPII predominantly localizes to the nucleus, but based on pathological conditions it also localizes in both cytoplasm and nucleus.
- NCBI登录号
- NM_016614
- UniProt
- O95551
-
You are here:
