RECQL2 抗体 (AA 122-240)
Quick Overview for RECQL2 抗体 (AA 122-240) (ABIN4886768)
抗原
See all RECQL2 (WRN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 122-240
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原理
- Anti-Werner's syndrome helicase WRN/WRN Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Werner's syndrome helicase WRN/WRN Antibody Picoband® (ABIN4886768). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E. coli-derived human WRN recombinant protein (Position: Q122-N240). Human WRN shares 84% amino acid (aa) sequence identity with mouse WRN.
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亚型
- IgG
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anti-Werner syndrome RecQ like helicase (WRN) (AA 1322-1432) antibody
WRN 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C11 unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (Internal Region) antibodyWRN 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (Center) antibodyWRN 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) antibodyWRN 适用: 人 WB, IHC, IF, ICC 宿主: 小鼠 Monoclonal 195C unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 787-816) antibodyWRN 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB17383 unconjugated
anti-Werner syndrome RecQ like helicase (WRN) antibodyWRN 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 1322-1432) antibodyWRN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2F7 unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 1322-1432) antibodyWRN 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 1223-1432) antibodyWRN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Werner syndrome RecQ like helicase (WRN) (AA 794-825), (Middle Region), (Thr802) antibodyWRN 适用: 人 WB, FACS, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Ding SL, Shen CY (2008). "Model of human aging: recent findings on Werner's and Hutchinson-Gilford progeria syndromes". Clin Interv Aging3 (3): 431-44. 2. Rossi ML, Ghosh AK, Bohr VA (2010). "Roles of Werner syndrome protein in protection of genome integrity". DNA Repair (Amst.) 9 (3): 331-44. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- RECQL2 (WRN) (Werner syndrome RecQ like helicase (WRN))
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别名
- WRN
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背景
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Synonyms: Werner syndrome ATP-dependent helicase,3.6.4.12 ,DNA helicase, RecQ-like type 3,RecQ3,Exonuclease WRN,3.1.-.-,RecQ protein-like 2,WRN,RECQ3, RECQL2,
Tissue Specificity: Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. .
Background: Werner syndrome ATP-dependent helicase, also known as DNA helicase, RecQ-like type 3, is an enzyme that in humans is encoded by the WRN gene. This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
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分子量
- 162 kDa, 200 kDa
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基因ID
- 7486
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UniProt
- Q14191
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途径
- DNA Damage Repair
抗原
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