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SET/TAF-I 抗体

This anti-SET/TAF-I antibody is a 兔 多克隆 antibody detecting SET/TAF-I in WB. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN4620361
发货至: 中国

Quick Overview for SET/TAF-I 抗体 (ABIN4620361)

抗原

See all SET/TAF-I (SET) 抗体
SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

适用

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宿主

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克隆类型

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多克隆

标记

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This SET/TAF-I antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 特异性

    This antibody detects I2PP2A / SET, widely expressed. Low levels in quiescent cells during serum starvation, contact inhibition or differentiation. Highly expressed in Wilms' tumor.

    纯化方法

    Affinity chromatography

    免疫原

    Synthetic peptide derived from the human SET protein

    亚型

    IgG
  • 应用备注

    Western blot (1: 400 dilution).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    Phosphate buffered saline with 0.08 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the product (in aliquots) at -20 °C to -70 °C. Can be shipped at 2 - 8 °C.
  • Shih, Shih, Lee, Huang, Wang, Chen, Tsai: "Particle size distributions and health-related exposures of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) of sinter plant workers." in: Chemosphere, (2009) (PubMed).

  • 抗原

    SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

    别名

    SET / I2PP2A

    背景

    Human SET was originally identified as part of the SET-CAN fusion gene produced by a somatic translocation event in a patient with acute undifferentiated leukemia. In developing kidney, SET is highly expressed in the zone of nephron morphogenesis. SET has been shown to be a potent and specific inhibitor of protein phosphatase 2A, a family of major serine/threonine phosphatases involved in regulating cell proliferation and differentiation. SET is also involved in the regulation of renal cell proliferation and tumorigenesis. SET mRNA expression is markedly reduced in cells rendered quiescent by serum starvation, contact inhibition, or differentiation. SET protein expression is also much greater in developing rat and human kidney than in fully differentiated, mature kidney. High levels of SET mRNA and SET protein expression arefound in Wilms' tumor, but not in renal cell carcinoma, adult polycystic kidney disease or in transitional cell carcinoma.Synonyms: I-2PP2A, IGAAD, Inhibitor of granzyme A-activated DNase, PHAPII, Phosphatase 2A inhibitor I2PP2A, TAF-I, Template-activating factor I

    基因ID

    6418

    NCBI登录号

    NP_001116293

    UniProt

    H0UI37

    途径

    Apoptosis
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