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PRMT5 抗体 (Internal Region)

PRMT5 适用: 人, 小鼠, 大鼠, 犬, Cow, Pig WB, EIA 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN401522
发货至: 中国
  • 抗原 See all PRMT5 抗体
    PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))
    抗原表位
    • 15
    • 10
    • 9
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 89
    • 36
    • 18
    • 7
    • 6
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    人, 小鼠, 大鼠, 犬, Cow, Pig
    宿主
    • 80
    • 6
    • 2
    • 1
    山羊
    克隆类型
    • 71
    • 17
    • 1
    多克隆
    标记
    • 48
    • 6
    • 6
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRMT5 antibody is un-conjugated
    应用范围
    • 65
    • 39
    • 37
    • 14
    • 14
    • 13
    • 13
    • 8
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    序列
    RACREKDRDP EAQ
    特异性
    This antibody detects PRMT5 (Internal). It is expected to recognize both isoforms (NP_006100.2, NP_001034708.1).
    交叉反应 (详细)
    Species reactivity (expected):Mouse, Rat, Pig, Dog, CowSpecies reactivity (tested):Human
    纯化方法
    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
    免疫原
    Peptide from the internal region of the protein sequence according to NP_006100.2, NP_001034708.1. Genename: PRMT5
    Top Product
    Discover our top product PRMT5 Primary Antibody
  • 应用备注
    Peptide ELISA: antibody detection limit dilution 1: 16000. Western blot: 1-3 μg/mL. Approx 70 kDa band observed in Jurkat lysates (calculated MW of72.0 kDa and 71.0 kDa according to NP_006100.2, NP_001034708.1).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
  • 抗原
    PRMT5 (Protein Arginine Methyltransferase 5 (PRMT5))
    别名
    PRMT5 (PRMT5 产品)
    别名
    HRMT1L5 antibody, IBP72 antibody, JBP1 antibody, SKB1 antibody, SKB1Hs antibody, Jbp1 antibody, Skb1 antibody, si:zc14a17.2 antibody, skb1 antibody, wu:fb95f10 antibody, zgc:110669 antibody, hsl7 antibody, DDBDRAFT_0187422 antibody, DDBDRAFT_0235403 antibody, DDB_0187422 antibody, DDB_0235403 antibody, NV18830 antibody, jbp1 antibody, ibp72 antibody, skb1hs antibody, hrmt1l5 antibody, protein arginine methyltransferase 5 antibody, protein arginine N-methyltransferase 5 antibody, protein arginine methyltransferase 5 L homeolog antibody, putative arginine N-methyltransferase, type II antibody, Skb1 family protein antibody, Protein arginine N-methyltransferase 5 antibody, PRMT5 antibody, Prmt5 antibody, prmt5 antibody, prmt5.L antibody, LOC100115766 antibody, prmt-5 antibody
    背景
    Arginine methylation is an irreversible post translational modification linked to protein activity. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins (Histone 2A, 3, 4), IL enhancer binding factor, nuclear factors (NF45, 90, ILF3, Nucleolin, STAT1, Poly(A) binding protein II), cell cycle proteins (phosphoprotein phosphatase 2A), signal transduction proteins (FGF2, Fibrillarin, FN, INFAR1, Jak, MBP, Src-adaptor Sam68), apoptosis proteins (FADD, ICE-like protease), and viral proteins (Hepatitis C NS3 RNA Helicase, HIV TAR). The mammalian PRMT family currently consists of 5 members that share two large domains of homology. Outside of these domains, epitopes were identified and antibodies against all five PRMT members have been developed. These antibodies can be utilized to explore arginine methylation and its regulatory functions.Synonyms: 72 kDa ICln-binding protein, HRMT1L5, Histone-arginine N-methyltransferase PRMT5, IBP72, JBP1, Jak-binding protein 1, Protein Arginine N-Methyltransferase 5, SKB1, SKB1Hs
    基因ID
    10419
    NCBI登录号
    NP_001034708
    UniProt
    O14744
    途径
    Chromatin Binding, Regulation of Muscle Cell Differentiation, Ribonucleoprotein Complex Subunit Organization, Skeletal Muscle Fiber Development
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