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WNT3 抗体 (Internal Region)

WNT3 适用: 人, 小鼠, 大鼠, 犬 WB, IHC (p), IF, EIA 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN374685
发货至: 中国
  • 抗原 See all WNT3 抗体
    WNT3 (Wingless-Type MMTV Integration Site Family, Member 3 (WNT3))
    抗原表位
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 29
    • 13
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬
    宿主
    • 28
    • 5
    • 2
    山羊
    克隆类型
    • 30
    • 5
    多克隆
    标记
    • 23
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    This WNT3 antibody is un-conjugated
    应用范围
    • 31
    • 17
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    特异性
    This antibody recognizes WNT3.
    交叉反应 (详细)
    Species reactivity (expected):Rat, Canine (Dog).
    Species reactivity (tested):Human, Mouse.
    纯化方法
    Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
    免疫原
    Peptide with sequence CGRGHNTRTEKRKEK, from the internal region of the protein sequence according to NP_110380.1. Genename: WNT3
    Top Product
    Discover our top product WNT3 Primary Antibody
  • 应用备注
    Peptide ELISA: 1/2000. Western Blot: 1 - 3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    WNT3 (Wingless-Type MMTV Integration Site Family, Member 3 (WNT3))
    别名
    WNT3 (WNT3 产品)
    别名
    INT4 antibody, Ci-Wnt3 antibody, WNT3 antibody, int4 antibody, Xwnt3 antibody, wnt-3 antibody, wnt3l antibody, Xwnt-3 antibody, wnt3 antibody, Int-4 antibody, Wnt-3 antibody, wnt3-A antibody, Wnt family member 3 antibody, wingless-type MMTV integration site family, member 3 antibody, proto-oncogene Wnt-3 antibody, wingless-type MMTV integration site family member 3 antibody, Wnt family member 3A antibody, wingless-type MMTV integration site family member 3 L homeolog antibody, WNT3 antibody, Wnt3 antibody, wnt3 antibody, LOC468297 antibody, WNT3A antibody, wnt3.L antibody
    背景
    Wnts have diverse roles in governing cell fate, proliferation, migration, and polarity during development, particularly in embryogenesis and carcinogenesis. WNTs are transduced through at least three distinct intracellular signaling pathways, including the canonical Wnt/b-catenin, Wnt/Ca2+ and Wnt polarity pathways. Distinct sets of Wnt and Frizzled ligand-receptor pairs activate each of these pathways and lead to unique cellular responses. Wnt3 is expressed in embryonic mouse brain (with peak expression at around day 12 of gestation) and at low levels in the adult. It is present in the cerebellum during mouse development, and is restricted to the Purkinje cell layer in the adult mouse. Wnt3 is required for normal limb development and plays an important role in the establishment of the apical ectodermal ridge. In motorneurons, Wnt3 is a retrograde signal that controls terminal branching of muscle afferents. Wnt3 is highly expressed in human cancer cell lines including A549 (lung cancer), MKN45 (gastric cancer) and MCF7 (breast cancer). Wnt3 and Wnt3a are nearly 90 % identical at the amino acid level.Synonyms: INT-4, INT4, Proto-oncogene protein Wnt-3
    基因ID
    7473, 9606
    UniProt
    P56703
    途径
    WNT signaling, Regulation of Cell Size
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