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NGFR 抗体 (Internal Region)

Name: NGFR 抗体 (Internal Region)
SKU: ABIN374571
Availability: OutOfStock

NGFR 适用: 人, 大鼠, 小鼠, 犬 WB 宿主: 山羊 Polyclonal unconjugated

Image no. 1 for anti-Nerve Growth Factor Receptor (NGFR) (Internal Region) antibody (ABIN374571) (NGFR 抗体 (Internal Region))

1 image

产品编号 ABIN374571

发货至: 中国

Datasheet as PDF

抗原 See all NGFR 抗体

NGFR (Nerve Growth Factor Receptor (NGFR))
抗原表位
16

13

9

8

6

6

6

5

4

4

4

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Internal Region
适用
159

59

55

29

27

26

26

21

11

5

4

4

3

3

2

2

2

1

1
人, 大鼠, 小鼠, 犬
宿主
92

72

4

1
山羊
Compatible Secondaries
克隆类型
89

80
多克隆
标记
89

15

10

7

6

4

3

3

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1
This NGFR antibody is un-conjugated
应用范围
103

80

57

55

45

28

27

19

18

14

14

12

9

6

4

3

3

2

1

1

1

1

1
Western Blotting (WB)

特异性

This antibody reacts to CD271.

交叉反应（详细）

Species reactivity (expected):Mouse, Rat, Canine, Bovine.
Species reactivity (tested):Human.

纯化方法

Affinity chromatography

免疫原

Peptide with sequence C-AKREEVEKLLNG, from the internal region of the protein sequence

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anti-Nerve Growth Factor Receptor (NGFR) antibody
NGFR 适用: 人 WB, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 2F1C2 unconjugated

anti-Nerve Growth Factor Receptor (NGFR) antibody
NGFR 适用: 人, 小鼠 WB, IF, ELISA, IHC 宿主: 小鼠 Monoclonal 8G3G10 unconjugated

anti-Nerve Growth Factor Receptor (NGFR) antibody
NGFR 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
浓度

0,5 mg/mL

缓冲液

Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C/-20 °C

储存方法

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
抗原

NGFR (Nerve Growth Factor Receptor (NGFR))

别名

CD271 / NGFR (NGFR 产品)

别名

ngfr antibody, wu:fb38c02 antibody, wu:fc10h01 antibody, CD271 antibody, Gp80-LNGFR antibody, TNFRSF16 antibody, p75(NTR) antibody, p75NTR antibody, LNGFR antibody, RNNGFRR antibody, Tnfrsf16 antibody, p75 antibody, NRH1b antibody, fullback antibody, nrh1 antibody, p75ntr antibody, tnfrsf16 antibody, p75NGFR antibody, nerve growth factor receptor antibody, neurotrophin receptor associated death domain antibody, nerve growth factor receptor S homeolog antibody, nerve growth factor receptor (TNFR superfamily, member 16) antibody, NGFR antibody, nradd antibody, Ngfr antibody, ngfr.S antibody

背景

Nerve Growth Factor Receptor, also termed NGFR p75, p75NTR, or CD271 is the low affinity NGFR (LNGFR) which binds NGF and other neurotrophins including BDNF, NT3, NT4/5 with similar, low affinity. NGFR p75 is a 75kD transmembrane glycoprotein (399 a.a.) consisting of an extracellular domain (222 a.a.) which contains four cysteine rich domains responsible for ligand binding, a transmembrane domain (22 a.a.), and a cytoplasmic domain (155 a.a.). NGFR p75 is mainly expressed in Schwann cells and neurons and in a variety of non neuronal cells. NGFR p75 is necessary for regulating neuronal growth, migration, differentiation and cell death during development of the central and peripheral nervous system. The signal transduction mechanisms and components leading to NGFR p75 multiple signals are complex and not well understood. In contrast to other members of the neurotrophin receptors family (TrkA, TrkB and TrkC tyrosine kinases), NGFR p75 lacks intrinsic catalytic activity. It has been suggested that NGFR p75 interacts with TrkA to form high affinity binding sites and to modulate TrkA signaling. NGFR p75 belongs to the TNF receptor superfamily which includes TNFR, CD40 and Fas. These receptors all have an intracellular death domain and can couple to parallel signaling pathways leading to apoptotic cell death or activation of the transcription factor NF kappaB. NGFR p75 plays a central role in the regulation of cell number by apoptosis in the developing CNS. During early development, activation of NGFR p75 by NGF induces apoptotic cell death in some neuronal cells, probably through activation of the sphingomyelinase/ceramide pathway, the ICE like proteases and the JNK pathway. In rat Schwann cells, NGF binding to NGFR p75 activates NF kappaB, possibly to modulate Schwann cell migration during nerve regeneration. CD271 has recently been described as being expressed in mesenchymal stem cells (bone marrow stromal cells).Synonyms: TNFRSF16, Tumor necrosis factor receptor superfamily member 16

基因ID

4804, 9606

UniProt

P08138

途径

NF-kappaB Signaling, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding