×
我们推荐在您的浏览器上开启Javascript,以获得最佳效果。
MEK1 抗体 (pThr292)
MAP2K1
适用: 人, 小鼠, 大鼠, 犬, Cow, Non-Human Primate
WB
宿主: 兔
Polyclonal
unconjugated
MEK1抗体详情
(hide)
抗原
See all MEK1 (MAP2K1) 抗体
MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
抗原表位
All epitopes for MEK1 抗体
pThr292
适用
All reactivities for MEK1 抗体
人, 小鼠, 大鼠, 犬, Cow, Non-Human Primate
宿主
All hosts for MEK1 抗体
兔
克隆类型
All clonalities for MEK1 抗体
多克隆
标记
All conjugates for MEK1 抗体
This MEK1 antibody is un-conjugated
应用范围
All applications for MEK1 抗体
Western Blotting (WB)
特异性
This antibody is specific for the ~45k MEK 1 protein phosphorylated at Thr292 in Western blots.
交叉反应 (详细)
Species reactivity (expected):Mouse, Human, Bovine, Canine and non-Human Primates. Species reactivity (tested):Rat.
纯化方法
Sequential Chromatography on phospho- and dephosphopeptide affinity columns.
免疫原
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr292 of human MEK1.
亚型
IgG
Top Product
Discover our top product MAP2K1 Primary Antibody
Alternatives
(show)
使用细节
(hide)
应用备注
Western blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
贮存及处理
(hide)
状态
Liquid
缓冲液
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
注意事项
Avoid repeated freezing and thawing.
储存条件
-20 °C
储存方法
Store the antibody undiluted (in aliquots) at-20 °C.
MEK1目标详情
(hide)
抗原
MEK1 (MAP2K1)
(Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1))
别名
MAP2K1 (MAP2K1 产品 )
别名
Mek1 antibody, CFC3 antibody, MAPKK1 antibody, MEK1 antibody, MKK1 antibody, PRKMK1 antibody, MEKK1 antibody, Prkmk1 antibody, mek-2 antibody, si:ch211-242m18.2 antibody, wu:fj56a12 antibody, wu:fj61b01 antibody, zgc:56557 antibody, ATMEK1 antibody, F20B18.180 antibody, F20B18_180 antibody, MAP kinase/ ERK kinase 1 antibody, MITOGEN ACTIVATED PROTEIN KINASE KINASE antibody, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 antibody, NMAPKK antibody, MEK antibody, mitogen activated protein kinase kinase 1 antibody, mitogen-activated protein kinase kinase 1 antibody, mitogen-activated protein kinase kinase 1 L homeolog antibody, MAP kinase/ ERK kinase 1 antibody, Map2k1 antibody, MAP2K1 antibody, map2k1.L antibody, map2k1 antibody, MEK1 antibody
背景
MEK1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993, Chong et al., 2003). This pathway also plays a key role in synaptic plasticity in the brain (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991, Seger et al., 1991, Crews et al., 1992). Conversely, there also appears to be a feedback phosphorylation of MEK 1 by MAP kinase. The sites on MEK 1 that are phosphorylated by MAP kinase are Thr292 and Thr386 (Mansour et al., 1994).Synonyms: Dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAP kinase kinase 1, MAPK/ERK kinase 1, MAPKK 1, MEK1, PRKMK1
基因ID
5604
NCBI登录号
NP_002746
UniProt
Q02750
途径
MAPK Pathway , RTK signaling , Interferon-gamma Pathway , Fc-epsilon Receptor Signaling Pathway , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Toll-Like Receptors Cascades , Autophagy , Signaling of Hepatocyte Growth Factor Receptor , BCR Signaling
Recently viewed
(hide)