GABRA6 抗体 (Cytoplasmic Loop)
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- 抗原 See all GABRA6 抗体
- GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
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抗原表位
- Cytoplasmic Loop
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适用
- 人, 大鼠, 小鼠, Cow
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GABRA6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Dot Blot (DB)
- 特异性
- Specific for the ~57k Alpha-6 subunit of the GABAA Receptor in Western blots of Rat brain membrane fractions. Also recognizes the alpha-6 subunit of GABAA-R in Bovine, Human amnd Mouse brain extracts. Does not recognizes GABAA-R subunits as reactivity is eliminated in alpha-6 knockout brain.
- 纯化方法
- Affinity Chromatography.
- 免疫原
- Fusion protein from the cytoplasmic loop of the Alpha-6 subunit of Rat GABAA Receptor.
- 亚型
- IgG
- Top Product
- Discover our top product GABRA6 Primary Antibody
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anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (N-Term) antibody
GABRA6 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Internal Region) antibodyGABRA6 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Cytoplasmic Domain) antibodyGABRA6 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Cytoplasmic Loop) antibodyGABRA6 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-30) antibodyGABRA6 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-37), (Extracellular), (N-Term) antibodyGABRA6 适用: 大鼠, 小鼠 WB, IHC, ICC, IF, LCI 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-242) antibodyGABRA6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 15-26) antibodyVerified GABRA6 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
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Western Blot: 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store the antibody undiluted (in aliquots) at-20 °C.
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- 抗原
- GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
- 别名
- GABAA Receptor alpha 6 (GABRA6 产品)
- 别名
- LOC100224835 antibody, GABRA6 antibody, Gabra-6 antibody, alpha6 antibody, si:dkey-217k23.1 antibody, zgc:73148 antibody, gamma-aminobutyric acid type A receptor alpha 6 subunit antibody, gamma-aminobutyric acid type A receptor alpha6 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 antibody, gamma-aminobutyric acid (GABA) A receptor, alpha 6a antibody, Gabra6 antibody, GABRA6 antibody, gabra6a antibody
- 背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, Pöltl et al., 2003).Synonyms: GABRA-6, GABRA6, Gamma-Aminobutyric Acid Receptor subunit Alpha-6
- 基因ID
- 29708
- NCBI登录号
- NP_068613
- UniProt
- P30191
- 途径
- Synaptic Membrane
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