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- 抗原 See all GABRA6 抗体
- GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
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抗原表位
- Cytoplasmic Loop
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适用
- 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GABRA6 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- Specific for the ~57k a6-subunit of the GABAA receptor in Western blots. Labeling is absent in a6-subunit knockout animals.
- 交叉反应
- 小鼠, 大鼠
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Fusion protein from the cytoplasmic loop of the alpha 6 subunit
- Top Product
- Discover our top product GABRA6 Primary Antibody
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anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (N-Term) antibody
GABRA6 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Internal Region) antibodyGABRA6 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (Cytoplasmic Domain) antibodyGABRA6 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-30) antibodyGABRA6 适用: 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-37), (Extracellular), (N-Term) antibodyGABRA6 适用: 大鼠, 小鼠 WB, IHC, ICC, IF, LCI 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 20-242) antibodyGABRA6 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6) (AA 15-26) antibodyVerified GABRA6 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 100 μL in 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.
- 储存条件
- -20 °C
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- 抗原
- GABRA6 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 6 (GABRA6))
- 别名
- GABRA6 (GABRA6 产品)
- 别名
- LOC100224835 antibody, GABRA6 antibody, Gabra-6 antibody, alpha6 antibody, si:dkey-217k23.1 antibody, zgc:73148 antibody, gamma-aminobutyric acid type A receptor alpha 6 subunit antibody, gamma-aminobutyric acid type A receptor alpha6 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 6 antibody, gamma-aminobutyric acid (GABA) A receptor, alpha 6a antibody, Gabra6 antibody, GABRA6 antibody, gabra6a antibody
- 背景
- Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six (s, four (s and four (s, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for (- and (-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a (-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different (-subunits of the receptor (McKernan et al., 2000, Mehta and Ticku, 1998, Ogris et al., 2004, P ltl et al., 2003). Anti-GABAA Receptor, a6-Subunit Western blot of mouse forebrain lysates from Wild Type (Control) and 6-knockout (6-K/O) animals showing specific immunolabeling of the ~57k a6-subunit of the GABAA-R. The labeling was absent from a lysate prepared from 6-knockout animals.
- 分子量
- '57 kDa
- 基因ID
- 29708
- UniProt
- P30191
- 途径
- Synaptic Membrane
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