ARHGEF11
适用: 人
WB, IF (cc), IF (p)
宿主: 兔
Polyclonal
Cy7
应用备注
Immunohistochemistry on Paraffin Sections: 10 μg/mL. Western Blot: 0.1-0.5 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
限制
仅限研究用
浓度
0.5 mg/mL
缓冲液
PBS containing 0.05 % Sodium Azide as preservative and 0.2 % Gelatin as stabilizer.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
ARHGEF11 (Rho guanine nucleotide exchange factor 11) acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. It exhibits transforming ability, associates with and modulates the actin cytoskeleton, regulates neurite outgrowth, and mediates activation of Rho in response to stimulation by activated Galpha12/13. Rat ARHGEF11 interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. ARHGEF11 is also thought to be involved in a pathway known to play a role in both insulin secretion and action.Synonyms: GTRAP48, KIAA0380, PDZ-RhoGEF, Rho guanine nucleotide exchange factor 11, RhoGEF glutamate transport modulator GTRAP48