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- 抗原 See all PIP5K1A 抗体
- PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PIP5K1A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody reacts to PIP5K1A.
- 纯化方法
- Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS
- 免疫原
- This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human PIP5K1A.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product PIP5K1A Primary Antibody
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anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 1-500) antibody
PIP5K1A 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 293-562) antibodyPIP5K1A 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (N-Term) antibodyPIP5K1A 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 19-50), (N-Term) antibodyPIP5K1A 适用: 人 WB 宿主: 兔 Polyclonal RB01727 unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) antibodyPIP5K1A 适用: 人, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A) (AA 258-347) antibodyPIP5K1A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
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ELISA: 1/1,000. Western blotting: 1/100 - 1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.25 mg/mL
- 缓冲液
- PBS with 0.09 % (W/V) sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
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- 抗原
- PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase, Type I, alpha (PIP5K1A))
- 别名
- PIP5K1A (PIP5K1A 产品)
- 别名
- Pip5k1b antibody, pip5k1c antibody, PIP5K1A antibody, pip5k1b antibody, Pipk5a antibody, Pipk5b antibody, pip5k1a antibody, zgc:110576 antibody, im:7140933 antibody, zgc:158838 antibody, phosphatidylinositol-4-phosphate 5-kinase type 1 alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha L homeolog antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, a antibody, phosphatidylinositol-4-phosphate 5-kinase, type I, alpha, b antibody, PIP5K1A antibody, Pip5k1a antibody, pip5k1a.L antibody, pip5k1a antibody, pip5k1aa antibody, pip5k1ab antibody
- 背景
- Overexpression of phosphatidylinositol phosphate 5-kinase alpha (PIP5KIalpha), which synthesizes PIP2, suppresses apoptosis, whereas a kinase-deficient mutant does not. Protection by the wild-type PIP5KIalpha isaccompanied by decreases in the generation of activated caspases and of caspase 3-cleaved PARP. Protection is not mediated through PIP3 or Akt activation. An anti-apoptotic role for PIP(2) is substantiated by the finding that PIP5KIalpha is cleaved by caspase 3 during apoptosis, and cleavage inactivates PIP5KIalpha in vitro. Mutation of the P(4) position (D279A) of the PIP5KIalpha caspase 3 cleavage consensus prevents cleavage in vitro, and during apoptosis in vivo. Significantly, the caspase 3-resistant PIP5KIalpha mutant is more effective in suppressing apoptosis than the wild-type kinase. PIP2 is a direct regulator of apical and effector caspases in the death receptor and mitochondrial pathways, and PIP5KIalpha inactivation contributes to the progression of apoptosis.Synonyms: 68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha, PIP5K1-alpha, PIP5KIalpha, Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha, PtdIns(4)P-5-kinase 1 alpha
- 基因ID
- 8394, 9606
- UniProt
- Q99755
- 途径
- PI3K-Akt Signaling, Mitotic G1-G1/S Phases, Inositol Metabolic Process, DNA Replication, Cell-Cell Junction Organization, Synthesis of DNA
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