c-MET 抗体 (pTyr1234, pTyr1235)
Quick Overview for c-MET 抗体 (pTyr1234, pTyr1235) (ABIN356338)
抗原
See all c-MET (MET) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pTyr1234, pTyr1235
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特异性
- This antibody detects MET/HGFR pTyr1234/1235.
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交叉反应 （详细）
- Species reactivity (tested):Human and Mouse.
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产品特性
- Synonyms: Hepatocyte growth factor receptor, MET, Scatter factor receptor, HGF/SF receptor, c-Met,Met proto-oncogene tyrosine kinase
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纯化方法
- Protein G Chromatography eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
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免疫原
- This monoclonal antibody is generated from mice immunized with a KLH conjugatedsynthetic peptide corresponding to sequences in Tyr1234/1235 region of human Met andresidues both Tyr1234 and Tyr1235 are phosphorylated.
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亚型
- IgG1
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anti-Met Proto-Oncogene (MET) (AA 25-150) antibody
MET 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (AA 743-932) antibodyMET 适用: 人, 猴 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5E9C4 unconjugated
anti-Met Proto-Oncogene (MET) (AA 1092-1379) antibodyMET 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) antibodyMET 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Monoclonal 2D12 unconjugated Recombinant Antibody
anti-Met Proto-Oncogene (MET) (C-Term) antibodyMET 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (AA 743-932) antibodyMET 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 5E9B7 unconjugated
anti-Met Proto-Oncogene (MET) (Internal Region) antibodyMET 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (Tyr1003) antibodyMET 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (AA 83-209) antibodyMET 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Met Proto-Oncogene (MET) (pTyr1349) antibodyMET 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA: 1/1,000. Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium Azide as preservative, 0.09 % (W/V) Sodium Azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
有效期
- 12 months
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- c-MET (MET) (Met Proto-Oncogene (MET))
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别名
- HGF Receptor
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背景
- MET/HGFR is a receptor for hepatocyte growth factor, with tyrosine-protein kinase activity. The MET/HGFR Type I membrane protein contains 1 Sema domain and consists of a heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. In the fully processed c-Met product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains as well as sites of tyrosine phosphorylation. Two isoforms for the protein have been described. Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. MET is overexpressed in a significant percentage of human cancers and is amplified during the transition between primary tumors and metastasis. Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC), also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance.Synonyms: HGF/SF receptor, Hepatocyte growth factor receptor, MET, Met proto-oncogene tyrosine kinase, Scatter factor receptor, c-Met
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基因ID
- 4233
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UniProt
- P08581
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途径
- RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
抗原
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