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PIN1 抗体 (N-Term)

PIN1 适用: 人 WB, EIA 宿主: 小鼠 Monoclonal 3G8 unconjugated
产品编号 ABIN320389
发货至: 中国
  • 抗原 See all PIN1 抗体
    PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
    抗原表位
    • 15
    • 13
    • 10
    • 9
    • 9
    • 8
    • 6
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-163, N-Term
    适用
    • 107
    • 51
    • 37
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 99
    • 12
    • 2
    • 1
    小鼠
    克隆类型
    • 102
    • 12
    单克隆
    标记
    • 55
    • 13
    • 12
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIN1 antibody is un-conjugated
    应用范围
    • 83
    • 46
    • 39
    • 30
    • 20
    • 18
    • 14
    • 13
    • 13
    • 12
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    纯化方法
    Protein-G affinity chromatography
    免疫原
    Recombinant human Pin1 (1-163 aa) purified from E. coli
    克隆位点
    3G8
    亚型
    IgG1
    Top Product
    Discover our top product PIN1 Primary Antibody
  • 应用备注
    ELISA. Western blot: 1/500-1/1,000, recommended starting dilution 1/500).
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.0 mg/mL
    缓冲液
    PBS, pH 7.4 with 0.09 % Sodium Azide as preservative.
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
    Shelf Life: one year from despatch.
    有效期
    12 months
  • 抗原
    PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
    别名
    PIN1 (PIN1 产品)
    别名
    DOD antibody, UBL5 antibody, dod antibody, ubl5 antibody, pin1 antibody, pin1a antibody, 0610025L01Rik antibody, D9Bwg1161e antibody, pin1b antibody, zgc:73206 antibody, PPIase pin1 antibody, MdPin1 antibody, Pin1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog antibody, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog antibody, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, peptidyl-prolyl cis-trans isomerase Pin1 antibody, PIN1 antibody, Pin1 antibody, pin1 antibody, pin1.S antibody, pin1.L antibody, ppiD antibody, PITG_11123 antibody, LOC103419188 antibody
    背景
    Human Pin1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation. Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA ,PLK I, Wee, and Myt1 kinases), several transcription factors like beta-Catenin, c-Jun, and the tumor suppressor protein p53 , and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.Synonyms: PIN-1, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Peptidyl-prolyl cis-trans isomerase Pin1
    UniProt
    Q13526
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