Retinoblastoma 1 抗体 (pSer795)
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北京 101111
Quick Overview for Retinoblastoma 1 抗体 (pSer795) (ABIN3201012)
抗原
See all Retinoblastoma 1 (RB1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer795
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特异性
- Specific to human Rb phosphorylated at Ser795.
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交叉反应 （详细）
- Not tested for other species. Can detect endogenous levels of Rb phosphorylated at Ser795 in most cell lines.
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纯化方法
- Purified
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过滤
- Sterile filtered
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免疫原
- A synthetic peptide containing pSer795 of human Rb
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亚型
- IgG2a kappa
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anti-Retinoblastoma 1 (RB1) (pSer780) antibody
RB1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer780) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer807) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer795) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (C-Term) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (C-Term) antibodyRB1 适用: 人 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (pSer807), (pSer811) antibodyRB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Retinoblastoma 1 (RB1) (AA 639-778) antibodyRB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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1. Western blotting: ~1 g/mL
2. ELISA
Other applications were not tested. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Store at -20 C (For long term storage: -70 C).
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: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, (1997) (PubMed).
: "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle." in: Cell, Vol. 75, Issue 4, pp. 779-90, (1993) (PubMed).
: "E2F: a link between the Rb tumor suppressor protein and viral oncoproteins." in: Science (New York, N.Y.), Vol. 258, Issue 5081, pp. 424-9, (1992) (PubMed).
: "The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations." in: The EMBO journal, Vol. 9, Issue 4, pp. 1147-55, (1990) (PubMed).
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: "Cancer cell cycles." in: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1672-7, (1997) (PubMed).
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- Retinoblastoma 1 (RB1)
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别名
- RB
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背景
- Retinoblastoma protein (Rb), the tumor suppressor product of the retinoblastoma susceptibility gene, is a 110 kDa protein that functions as a negative regulator of the cell cycle by arresting cells in the G1 phase and halting inappropriate cell proliferation. At the transcriptional level, Rb protein exerts its growth suppressive function by binding to transcription factors including E2F1, PU1, ATF2, UBF, Elf-1 and c-Abl. Loss of Rb function leads to uncontrolled cell growth and tumor development and is found in all retinoblastomas and in a variety of other human malignancies. The ability of Rb protein to inhinbit transcription and cell cycle progression is inactivated by hosphorylation, which is catalyzed by the cyclin-dependent protein kinases.
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UniProt
- P06400
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途径
- Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
抗原
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