p53 抗体 (acLys315)
(3 references)Quick Overview for p53 抗体 (acLys315) (ABIN3201007)
抗原
See all p53 (TP53) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- acLys315
-
产品特性
- This product is the purified IgG fraction obtained from serum-free culture medium of mouse hybridoma (clone 10E5), which produces monoclonal antibody that specifically recognizes human p53 protein with acetylated Lys120.
-
纯化方法
- Purified
-
免疫原
- synthetic peptide containing acLys315
-
亚型
- IgG1 kappa
-
-
anti-Tumor Protein P53 (TP53) (pSer392) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 1-100) antibodyTP53 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) antibodyKO Validated TP53 适用: 人 WB, IF, IHC (p), IP, ICC, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (N-Term) antibodyTP53 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 301-393) antibodyTP53 适用: 人, 小鼠, 大鼠, 山羊 WB, ELISA, FACS, IHC (p), ICC, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (pSer33) antibodyTP53 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (AA 94-201) antibodyTP53 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-Tumor Protein P53 (TP53) (AA 94-201) antibodyTP53 适用: 人 WB, ELISA, IHC (p), PLA, RNAi 宿主: 小鼠 Monoclonal 2C11 unconjugated
anti-Tumor Protein P53 (TP53) (pSer20) antibodyTP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Protein P53 (TP53) (pSer15) antibodyTP53 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- 1. Western blotting: ~1 g/mL
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- PBS ( pH 7.4), 50 % glycerol
-
储存液
- Azide free
-
储存条件
- -20 °C
-
储存方法
- Upon arrival centrifuge briefly and store at -20 C.
-
-
-
: "To die or not to die: a HAT trick." in: Molecular cell, Vol. 24, Issue 6, pp. 807-8, (2006) (PubMed).
: "Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis." in: Molecular cell, Vol. 24, Issue 6, pp. 827-39, (2006) (PubMed).
: "Acetylation of the p53 DNA-binding domain regulates apoptosis induction." in: Molecular cell, Vol. 24, Issue 6, pp. 841-51, (2006) (PubMed).
-
: "To die or not to die: a HAT trick." in: Molecular cell, Vol. 24, Issue 6, pp. 807-8, (2006) (PubMed).
-
- p53 (TP53) (Tumor Protein P53 (TP53))
-
别名
- p53
-
背景
- P53 mutants are found in more than half of human cancers and are considered as the most important human cancer related gene. p53 is detected at 53kD position by electrophoresis and is composed of 393 amino acids. In the unstressed normal cells, the p53 level is low and it is inactive. However, with stress, especially with DNA damage, it is activated to promote arrest of cell cycle and repair of DNA damage, or induction of apoptosis. The functions and stability of p53 are regulated by phosphorylation of serine and threonine, and acetylation of lysine at various sites in the molecule. Acetylation of lysine 120 (acetyl-K120) of p53 occurs rapidly after DNA damage and is catalyzed by the MYST family acetyltransferases hMOF and TIP60, and activates transcription of proapoptotic genes, BAX and PUMA.
-
UniProt
- P04637
-
途径
- p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
抗原
-
