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p53 抗体 (pSer20)

Name: p53 抗体 (pSer20)
SKU: ABIN3201004
Availability: OutOfStock

This anti-p53 antibody is a 小鼠单克隆 antibody detecting p53 in WB 和 ELISA. Suitable for 人. This Primary Antibody has been cited in 3+ publications.

Western Blotting (WB) image for anti-Tumor Protein P53 (TP53) (pSer20) antibody (ABIN3201004) (p53 抗体 (pSer20))

1 image

(3 references)

产品编号 ABIN3201004

发货至: 中国

Datasheet as PDF

Quick Overview for p53 抗体 (pSer20) (ABIN3201004)

抗原

See all p53 (TP53) 抗体

p53 (TP53) (Tumor Protein P53 (TP53))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This p53 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA

克隆位点

17B6

Discover our top product TP53 Primary Antibody

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pSer20

纯化方法

Purified

过滤

Sterile filtered

免疫原

synthetic peptide containing pSer20

亚型

IgG1 kappa
anti-Tumor Protein P53 (TP53) (pSer392) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 1-100) antibody
TP53 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) antibody
KO Validated TP53 适用: 人 WB, IF, IHC (p), IP, ICC, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (N-Term) antibody
TP53 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 301-393) antibody
TP53 适用: 人, 小鼠, 大鼠, 山羊 WB, ELISA, FACS, IHC (p), ICC, IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (pSer33) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (AA 94-201) antibody
TP53 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 2C3 unconjugated

anti-Tumor Protein P53 (TP53) (AA 94-201) antibody
TP53 适用: 人 WB, ELISA, IHC (p), PLA, RNAi 宿主: 小鼠 Monoclonal 2C11 unconjugated

anti-Tumor Protein P53 (TP53) (pSer20) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Tumor Protein P53 (TP53) (pSer15) antibody
TP53 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

1) Western blotting: ~ 1 g/mL
2) ELISA

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

PBS, 50 % glycerol

储存液

Azide free

储存条件

-20 °C/-80 °C

储存方法

-20 C (For long term storage: -70 C)
Bode, Dong: "Post-translational modification of p53 in tumorigenesis." in: Nature reviews. Cancer, Vol. 4, Issue 10, pp. 793-805, (2004) (PubMed).

Hirao, Kong, Matsuoka, Wakeham, Ruland, Yoshida, Liu, Elledge, Mak: "DNA damage-induced activation of p53 by the checkpoint kinase Chk2." in: Science (New York, N.Y.), Vol. 287, Issue 5459, pp. 1824-7, (2000) (PubMed).

Shieh, Taya, Prives: "DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization." in: The EMBO journal, Vol. 18, Issue 7, pp. 1815-23, (1999) (PubMed).
抗原

p53 (TP53) (Tumor Protein P53 (TP53))

别名

p53

背景

P53 mutants are found in more than half of human cancers and are considered as the most important human cancer related gene. p53 is detected at 53kD position by electrophoresis and is composed of 393 amino acids. In the unstressed normal cells, the p53 level is low and it is inactive. However, with stress, especially with DNA damage, it is activated to promote arrest of cell cycle and repair of DNA damage, or induction of apoptosis. The functions of p53 are regulated by phosphorylation of serine and threonine, and acetylation of lysine at various sites in the molecule. p53 at Ser20 is phosphorylated by Chk1 and Chk2 kinases and this enhances tetramerization, stability and activity of p53.

UniProt

P04637

途径

p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect