p53 抗体
Quick Overview for p53 抗体 (ABIN306557)
抗原
See all p53 (TP53) 抗体适用
宿主
克隆类型
标记
应用范围
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亚型
- IgG
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限制
- 仅限研究用
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浓度
- 1 mg/ml
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储存条件
- -20 °C
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- p53 (TP53) (Tumor Protein P53 (TP53))
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别名
- p53
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背景
- GST p53 fusion protein containing amino acids 1-393 of human p53was used as immunogen. p53 has a molecular weight of 53kDa p53 is a transcription factor that can inhibit cell cycle progression or induce apoptosis in response to stress or DNA damage. Disruption of the p53 signalling pathway through various mechanisms is the most common alteration in human cancer occuring in over half of all tumors. The p53 protein is short lived and expressed at low levels in normal cells but accumulates and/or is activated in cells that have undergone genotoxic damage or oncogene activation. Many tumor derived and transformed cell lines express elevated levels of mutant p53 protein. Synonyms: Sheep anti human p53, hp53.
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UniProt
- P04637
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途径
- p53 Pathway, MAPK Pathway, PI3K-Akt Signaling, Apoptosis, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, Warburg Effect
抗原
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