SLC12A1 抗体 (N-Term)
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Quick Overview for SLC12A1 抗体 (N-Term) (ABIN3043925)
抗原
See all SLC12A1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 52-83, N-Term
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原理
- Anti-SLC12A1 Antibody
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序列
- DEAQKRLRIS FRPGNQECYD NFLQSGETAK TD
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交叉反应 (详细)
- No cross-reactivity with other proteins.
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产品特性
- Anti-SLC12A1 Antibody (ABIN3043925). Tested in IF, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human SLC12A1, different from the related mouse sequence by two amino acids, and from the related rat sequence by four amino acids.
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亚型
- IgG
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应用备注
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Western blot, 0.25-0.5 μg/mL, Monkey, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
Immunofluorescence, 5 μg/mL, Mouse, Rat
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- SLC12A1 (Solute Carrier Family 12 (Sodium/potassium/chloride Transporters), Member 1 (SLC12A1))
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别名
- SLC12A1
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背景
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Synonyms: Solute carrier family 12 member 1,Bumetanide-sensitive sodium- (potassium)-chloride cotransporter 2,Kidney-specific Na-K-Cl symporter,SLC12A1,NKCC2,
Tissue Specificity: Kidney specific.
Background: Solute carrier family 12 (sodium/potassium/chloride transporters), member 1, also called NKCC2 is specifically found in cells of the thick ascending limb of the loop of Henle in nephrons, the basic functional units of the kidney. This gene is mapped to 15q21.1. This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. This gene plays a vital role in the regulation of ionic balance and cell volume.
Sequence Similarities: Contains 1 PID domain.
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分子量
- 150-290 kDa
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基因ID
- 6557
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UniProt
- Q13621
抗原
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