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Lamin A/C 抗体 (C-Term)

Name: Lamin A/C 抗体 (C-Term)
SKU: ABIN3043695
Availability: OutOfStock

LMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

Anti-Lamin A+C antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: A431 Cell Lysate (Lamin A/C 抗体 (C-Term))

Anti-Lamin A+C antibody, IHC(P) IHC(P): Rat Intestine Tissue (Lamin A/C 抗体 (C-Term))

IHC

Anti-Lamin A+C antibody, IHC(P) IHC(P): Mouse Intestine Tissue (Lamin A/C 抗体 (C-Term))

IHC

Anti-Lamin A+C antibody, IHC(P) IHC(P): Human Lung Cancer Tissue (Lamin A/C 抗体 (C-Term))

IHC

4 images

(3 references)

产品编号 ABIN3043695

发货至: 中国

Datasheet as PDF

抗原 See all Lamin A/C (LMNA) 抗体

Lamin A/C (LMNA)
抗原表位
9

9

7

7

5

5

5

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 455-469, C-Term
适用
142

82

78

26

15

12

8

7

6

6

5

5

4

3

3

2

2

1

1

1

1

1

1

1
人, 小鼠, 大鼠
宿主
111

48

2

1
兔
Compatible Secondaries
克隆类型
109

53
多克隆
标记
125

9

8

6

2

2

2

2

1

1

1

1

1

1
This Lamin A/C antibody is un-conjugated
应用范围
130

67

58

52

41

36

27

20

12

7

3

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

原理

Anti-Lamin A + C/LMNA Antibody Picoband®

序列

RNKSNEDQSM GNWQI

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Lamin A + C/LMNA Antibody (ABIN3043695). Tested in IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of human Lamin A/C, identical to the related rat and mouse sequences.

亚型

IgG

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anti-Lamin A/C (LMNA) antibody
KO Validated LMNA 适用: 人 WB, IF, IP, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (pSer392) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
KO Validated LMNA 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人 IHC, ELISA, IF, IP, FACS 宿主: 兔 Monoclonal 4H7 unconjugated Recombinant Antibody

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4E7 unconjugated

anti-Lamin A/C (LMNA) (AA 481-646) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) (AA 455-469) antibody
LMNA 适用: 人, 小鼠, 大鼠 WB, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Lamin A/C (LMNA) antibody
LMNA 适用: 人, 小鼠, 大鼠, Cow, 犬 WB, IHC, ICC, FACS, IHC (fro) 宿主: 小鼠 Monoclonal 133A2 unconjugated

anti-Lamin A/C (LMNA) (C-Term) antibody
LMNA 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 猴, 兔, 马, Hamster, 小鸡, 绵羊, 豚鼠, Avian, Cat, 驴, 山羊 WB 宿主: 山羊 Polyclonal unconjugated

应用备注

Immunocytochemistry , 0.5-1 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Lammerding, J., Schulze, P. C., Takahashi, T., Kozlov, S., Sullivan, T., Kamm, R. D., Stewart, C. L., Lee, R. T. : Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction. J. Clin. Invest. 113: 370-378, 2004. 2. Lin, F., Worman, H. J. : Structural organization of the human gene encoding nuclear lamin A and nuclear lamin C. J. Biol. Chem. 268: 16321-16326, 1993. 3. Wydner, K. L., McNeil, J. A., Lin, F., Worman, H. J., Lawrence, J. B. : Chromosomal assignment of human nuclear envelope protein genes LMNA, LMNB1, and LBR by fluorescence in situ hybridization. Genomics 32: 474-478, 1996.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Jevti?, Edens, Li, Nguyen, Chen, Levy: "Concentration-dependent Effects of Nuclear Lamins on Nuclear Size in Xenopus and Mammalian Cells." in: The Journal of biological chemistry, Vol. 290, Issue 46, pp. 27557-71, (2015) (PubMed).

Liu, Ma, Wu, Li, Zhang, Han, Wang, Reindl, Wu, Ma: "Arginine deiminase augments the chemosensitivity of argininosuccinate synthetase-deficient pancreatic cancer cells to gemcitabine via inhibition of NF-?B signaling." in: BMC cancer, Vol. 14, pp. 686, (2014) (PubMed).

Yang, Liu, Zhu, Zhang, Xi, Hu, He, Jiang: "Human peripheral nerve-derived scaffold for tissue-engineered nerve grafts: histology and biocompatibility analysis." in: Journal of biomedical materials research. Part B, Applied biomaterials, Vol. 96, Issue 1, pp. 25-33, (2010) (PubMed).
抗原

Lamin A/C (LMNA)

别名

LMNA (LMNA 产品)

背景

Synonyms: Prelamin-A/C,Lamin-A/C,70 kDa lamin,Renal carcinoma antigen NY-REN-32,LMNA,LMN1,
Tissue Specificity: In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress. .
Background: Lamins are structural protein components of the nuclear lamina, a protein network underlying the inner nuclear membrane that determines nuclear shape and size. There are three types of lamins, A,B and C. The lamin A/C (LMNA) gene contains 12 exons. Alternative splicing within exon 10 gives rise to two different mRNAs that code for pre-lamin A and lamin C. Lamin A/C mapped to 1q21.2-q21.3 and mutations in this gene cause a variety of human diseases including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy, and Hutchinson-Gilford progeria syndrome. Lamin A/C deficiency is thus associated with both defective nuclear mechanics and impaired mechanically activated gene transcription.
Sequence Similarities: Belongs to the intermediate filament family.

分子量

70-74 kDa

UniProt

P02545

途径

Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus