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- 抗原 See all NR4A1 抗体
- NR4A1 (Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NR4A1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- Antigen affinity
- 免疫原
- An amino acid sequence from the N-terminus of the human protein (ASFKFEDFQVYGCY) was used as the immunogen for this NUR77 antibody (100% homologous in human, mouse and rat).
- 亚型
- Ig Fraction
- Top Product
- Discover our top product NR4A1 Primary Antibody
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anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (N-Term) antibody
NR4A1 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (AA 1-170) antibodyNR4A1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (Ser351) antibodyNR4A1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (C-Term) antibodyNR4A1 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (AA 351-450) antibodyNR4A1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (Ser474) antibodyNR4A1 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (AA 251-266) antibodyNR4A1 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (AA 324-373) antibodyNR4A1 适用: 人, 犬, Cow, 马, 兔, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (AA 1-598) antibodyNR4A1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1) (Internal Region) antibodyVerified NR4A1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
- The stated application concentrations are suggested starting points. Titration of the NUR77 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
- 限制
- 仅限研究用
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- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the NUR77 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- 抗原
- NR4A1 (Nuclear Receptor Subfamily 4, Group A, Member 1 (NR4A1))
- 别名
- NUR77 (NR4A1 产品)
- 别名
- GFRP1 antibody, HMR antibody, N10 antibody, NAK-1 antibody, NGFIB antibody, NP10 antibody, NUR77 antibody, TR3 antibody, NGFI-B antibody, Gfrp antibody, Hbr-1 antibody, Hbr1 antibody, Hmr antibody, TIS1 antibody, nur77 antibody, Ngfi-b antibody, Nur77 antibody, nuclear receptor subfamily 4 group A member 1 antibody, nuclear receptor subfamily 4, group A, member 1 antibody, NR4A1 antibody, Nr4a1 antibody
- 背景
- Nuclear receptor subfamily 4 group A member 1, also called NAK1, GFRP1, TR3, NUR77 or NGFIB, is a protein that in humans is encoded by the NR4A1 gene, and is a member of the Nur nuclear receptor family of intracellular transcription factors. NR4A1 is involved in cell cycle mediation, inflammation and apoptosis. It plays a key role in mediating inflammatory responses in macrophages. In addition, subcellular localization of the protein appears to play a key role in the survival and death of cells. Nr4a1 was overexpressed in Wnt1 -transformed mouse mammary cells. It was also induced by lithium, a Wnt1 mimic, and the promoter was activated by lithium and beta-catenin, a Wnt1 downstream effector. In contrast, human NR4A1 was not upregulated by beta-catenin, indicating that this gene is regulated differently in human and mouse cells. Adenoviral expression of Nr4a1 induced genes involved in gluconeogenesis, stimulated glucose production both in vitro and in vivo, and raised blood glucose levels.
- UniProt
- P22736
- 途径
- Fc-epsilon Receptor Signaling Pathway, Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Steroid Hormone Mediated Signaling Pathway
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