Hexosaminidase A 抗体 (Middle Region)
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- 抗原 See all Hexosaminidase A (HEXA) 抗体
- Hexosaminidase A (HEXA)
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抗原表位
- Middle Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Hexosaminidase A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Antigen affinity
- 免疫原
- An amino acid sequence from the middle region of human Hexosaminidase A, alpha subunit (DVMAYNKLNVFHWHLVD) was used as the immunogen for this HEXA antibody.
- 亚型
- IgG
- Top Product
- Discover our top product HEXA Primary Antibody
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anti-Hexosaminidase A (HEXA) (AA 318-529) antibody
HEXA 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase A (HEXA) antibodyHEXA 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase A (HEXA) (Internal Region) antibodyHEXA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase A (HEXA) (AA 1-529) antibodyHEXA 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3D1 unconjugated
anti-Hexosaminidase A (HEXA) antibodyHEXA 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 3F10 unconjugated
anti-Hexosaminidase A (HEXA) (AA 142-170), (N-Term) antibodyHEXA 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20977 unconjugated
anti-Hexosaminidase A (HEXA) (AA 1-529) antibodyHEXA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3D1 unconjugated
anti-Hexosaminidase A (HEXA) antibodyHEXA 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS 宿主: 小鼠 Monoclonal unconjugated
anti-Hexosaminidase A (HEXA) (AA 319-528) antibodyHEXA 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase A (HEXA) (AA 89-529) antibodyHEXA 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- The stated application concentrations are suggested starting amounts. Titration of the HEXA antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
- 限制
- 仅限研究用
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- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the HEXA antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- 抗原
- Hexosaminidase A (HEXA)
- 别名
- HEXA (HEXA 产品)
- 别名
- TSD antibody, fc04h11 antibody, wu:fc04h11 antibody, wu:fv09f06 antibody, si:dkey-35i22.2 antibody, HEXA antibody, Hex-1 antibody, zgc:112084 antibody, hexosaminidase subunit alpha antibody, hexosaminidase B (beta polypeptide) antibody, CUGBP Elav-like family member 6 antibody, hexosaminidase A antibody, hexosaminidase A (alpha polypeptide) antibody, beta-hexosaminidase subunit alpha-like antibody, HEXA antibody, hexb antibody, CELF6 antibody, Hexa antibody, hexa antibody, LOC100228061 antibody
- 背景
- HEXA (Hexosaminidase A) is an enzyme that in humans is encoded by the HEXA gene. Hexosaminidase A and the cofactor GM2 activator protein catalyze the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines The HEXA gene encodes the alpha subunit of hexosaminidase A, a lysosomal enzyme involved in the breakdown of gangliosides. Even though the alpha and beta subunits of hexosaminidase A can both cleave GalNAc residues, only the alpha subunit is able to hydrolyze GM2 gangliosides. The alpha subunit contains a key residue, Arg-424, which is essential for binding the N-acetyl-neuramanic residue of GM2 gangliosides. Chimeric constructs were expressed in HeLa cells and selected constructs were produced in the baculovirus expression system to determine their ability to degrade GM2 ganglioside in the presence of GM2 activator protein. Their results allowed them to define two noncontiguous sequences in the alpha subunit (amino acids 1-191 and 403-529) which, when substituted into analogous positions in the beta subunit, conferred activity against the sulfated substrate.
- UniProt
- P06865
- 途径
- Sensory Perception of Sound, Glycosaminoglycan Metabolic Process
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