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GLI2 抗体 (C-Term)

GLI2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3031040
发货至: 中国
  • 抗原 See all GLI2 抗体
    GLI2 (GLI Family Zinc Finger 2 (GLI2))
    抗原表位
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 41
    • 12
    • 4
    • 1
    • 1
    宿主
    • 40
    • 2
    • 1
    克隆类型
    • 41
    • 2
    多克隆
    标记
    • 19
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    This GLI2 antibody is un-conjugated
    应用范围
    • 16
    • 10
    • 9
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    Antigen affinity
    免疫原
    An amino acid sequence from the C-terminus of human GLI-2 (MLYYYGQIHMYEQDGGLENL) was used as the immunogen for this GLI2 antibody.
    亚型
    IgG
    Top Product
    Discover our top product GLI2 Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting amounts. Titration of the Gli2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
    1. GLI2 exists as five alternatively spliced isoforms of 133 kDa (isoform 1), 132 (2), 88 (3), 86 (4) and 168 kDa (isoform 5).\. Western blot: 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the GLI2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    GLI2 (GLI Family Zinc Finger 2 (GLI2))
    别名
    GLI2 (GLI2 产品)
    别名
    HPE9 antibody, THP1 antibody, THP2 antibody, GLI2/GLI4 antibody, GLI3 antibody, AW546128 antibody, GLI family zinc finger 2 antibody, GLI-Kruppel family member GLI2 antibody, GLI2 antibody, Gli2 antibody
    背景
    Gli-Kruppel Family Member 2 is a protein that in humans is encoded by the GLI2 gene. Sequencing of GLI cDNA clones showed the presence of 5 tandem zinc fingers connected by histidine-cysteine links, which indicated that the gene belongs to the family of zinc finger genes related to Kruppel(Kr). The Drosophila gene Kr is a member of the gap class of segmentation genes, thoracic and anterior abdominal segments fail to form in Kr mutant embryos. By fluorescence in situ hybridization, Matsumoto et al.(1996) refined the assignment of the GLI2 gene to chromosome 2q14. Roessler et al.(2005) showed that GLI2-delta-N exhibited potent transcriptional activity in vivo: overexpression in mouse skin led to the formation of hedgehog-independent epithelial downgrowths resembling basal cell carcinomas, which in humans are associated with constitutive hedgehog signaling.
    UniProt
    P10070
    途径
    Hedgehog Signaling, Dopaminergic Neurogenesis
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