RAD51 抗体 (AA 1-258)
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北京 101111
Quick Overview for RAD51 抗体 (AA 1-258) (ABIN3030760)
抗原
See all RAD51 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-258
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纯化方法
- Antigen affinity
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免疫原
- Human partial recombinant protein (AA 1-258) was used as the immunogen for this Rad51 antibody.
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亚型
- IgG
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the Rad51 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the Rad51 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- RAD51 (DNA Repair Protein Homolog 1 (RAD51))
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别名
- Rad51
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背景
- DNA repair protein RAD51 homolog 1, also known as RAD51A, is a human gene. The Rad51 gene, HsRAD51, is a homolog of RecA of Escherichia coli and functions in recombination and DNA repair. BRCA1 and BRCA2 proteins form a complex with Rad51, and these genes are thought to participate in a common DNA damage response pathway associated with the activation of homologous recombination and double-strand break repair. It is found to interact with < a href=../search_result.php?search_txt=brca>BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis.
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基因ID
- 5888
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途径
- DNA Damage Repair
抗原
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