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Vitamin D Receptor 抗体 (C-Term)

VDR 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3029598
发货至: 中国
  • 抗原 See all Vitamin D Receptor (VDR) 抗体
    Vitamin D Receptor (VDR)
    抗原表位
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    C-Term
    适用
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    人, 小鼠, 大鼠
    宿主
    • 97
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    克隆类型
    • 91
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    多克隆
    标记
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    This Vitamin D Receptor antibody is un-conjugated
    应用范围
    • 84
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    Western Blotting (WB)
    纯化方法
    Antigen affinity
    免疫原
    An amino acid sequence from the C-terminus of human Vitamin D Receptor (DLRSLNEEHSKQYRCL) was used as the immunogen for this VDR antibody.
    亚型
    IgG
    Top Product
    Discover our top product VDR Primary Antibody
  • 应用备注
    The stated application concentrations are suggested starting amounts. Titration of the VDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the VDR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    Vitamin D Receptor (VDR)
    别名
    VDR (Vitamin D Receptor) (VDR 产品)
    别名
    vdrbeta antibody, vdr0 antibody, LOC100136219 antibody, NR1I1-B antibody, gb:dq017633 antibody, vdr-b antibody, Ci-VDR-b antibody, VDR antibody, LOC100221284 antibody, vdr-A antibody, xVDR antibody, Nr1i1 antibody, vdr antibody, NR1I1 antibody, PPP1R163 antibody, vitamin D (1,25- dihydroxyvitamin D3) receptor antibody, vitamin D receptor antibody, vitamin D3 receptor A antibody, vitamin D receptor b antibody, nuclear receptor VDR-b antibody, vitamin D (1,25- dihydroxyvitamin D3) receptor L homeolog antibody, vitamin D (1,25-dihydroxyvitamin D3) receptor antibody, vitamin D receptor a antibody, vdr antibody, vdr0 antibody, VDR antibody, LOC100136219 antibody, vdrb antibody, vdr-b antibody, vdr.L antibody, Vdr antibody, vdra antibody
    物质类
    Chemical
    背景
    Vitamin D Receptor, also known as Vitamin D Hormone Receptor, is a member of the nuclear receptor family of transcription factors. Labuda et al.(1991) assigned the VDR gene to 12q12-q14 by in situ hybridization. Using mutation analysis, Jurutka et al.(2000) characterized arg18/arg22, VDR residues immediately N-terminal of the first DNA-binding zinc finger, as vital for contact with the general transcription factor IIB(TFIIB). A natural polymorphic variant of the receptor, termed F/M4(missing a FokI restriction site), which lacks only the first 3 amino acids(including glu2), interacted more efficiently with TFIIB and also possessed elevated transcriptional activity compared with the full-length(f/M1) receptor. Shah et al.(2006) stated that the signaling and oncogenic activity of beta-catenin(CTNNB1) can be repressed by activation of VDR. Conversely, high levels of beta-catenin can potentiate the transcriptional activity of 1,25-dihydroxyvitamin D3.
    UniProt
    P11473
    途径
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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