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LAMP3 抗体

LAMP3 适用: 人 IF, FACS 宿主: 小鼠 Monoclonal LAMP3-529 unconjugated
产品编号 ABIN3023873
发货至: 中国
  • 抗原 See all LAMP3 抗体
    LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This LAMP3 antibody is un-conjugated
    应用范围
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    Immunofluorescence (IF), Flow Cytometry (FACS)
    产品特性
    This mAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
    纯化方法
    Protein G affinity chromatography
    免疫原
    Recombinant human protein was used as the immunogen for the LAMP3 antibody.
    克隆位点
    LAMP3-529
    亚型
    IgG2a kappa
    Top Product
    Discover our top product LAMP3 Primary Antibody
  • 应用备注
    Optimal dilution of the LAMP3 antibody should be determined by the researcher.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL
    限制
    仅限研究用
  • 浓度
    0.2 mg/mL
    缓冲液
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store the LAMP3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • 抗原
    LAMP3 (Lysosomal-Associated Membrane Protein 3 (LAMP3))
    别名
    LAMP3 (LAMP3 产品)
    别名
    DC-LAMP antibody, CD208 antibody, DC LAMP antibody, DCLAMP antibody, LAMP antibody, LAMP-3 antibody, TSC403 antibody, 1200002D17Rik antibody, Cd208 antibody, lysosomal associated membrane protein 3 antibody, lysosomal-associated membrane protein 3 antibody, LAMP3 antibody, Lamp3 antibody
    背景
    This mAb recognizes protein of 26  kDa-60  kDa, which is identified as CD63/LAMP3. Its epitope is different from that of mAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63/LAMP3 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. It is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63/LAMP3 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. Deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression.
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