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Insulin 抗体 (AA 1-110)

This anti-Insulin antibody is a 兔 多克隆 antibody detecting Insulin in IHC, WB 和 IF. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN3022885
发货至: 中国

Quick Overview for Insulin 抗体 (AA 1-110) (ABIN3022885)

抗原

See all Insulin (INS) 抗体
Insulin (INS)

适用

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宿主

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克隆类型

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多克隆

标记

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This Insulin antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)
  • 抗原表位

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    AA 1-110

    序列

    MALWMRLLPL LALLALWGPD PAAAFVNQHL CGSHLVEALY LVCGERGFFY TPKTRREAED LQVGQVELGG GPGAGSLQPL ALEGSLQKRG IVEQCCTSIC SLYQLENYCN

    交叉反应

    人, 小鼠, 大鼠

    产品特性

    Polyclonal Antibodies

    免疫原

    Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human INS (NP_000198.1).

    亚型

    IgG
  • 应用备注

    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid freeze / thaw cycles

    储存条件

    -20 °C

    储存方法

    Store at -20°C. Avoid freeze / thaw cycles.
  • Chen, Zeng, Liu, Guo, Zhang, Chen, Lin, Wen, Zhao, Lin, Gao: "Adropin deficiency worsens HFD-induced metabolic defects." in: Cell death & disease, Vol. 8, Issue 8, pp. e3008, (2018) (PubMed).

  • 抗原

    Insulin (INS)

    别名

    INS

    背景

    After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.,IDDM,IDDM1,IDDM2,ILPR,IRDN,MODY10,INS,Insulin,insulin,Cancer,Signal Transduction,Cell Biology & Developmental Biology,Growth factor,Endocrine & Metabolism,AMPK Signaling Pathway,Endocrine and metabolic diseases,Diabetes,Obesity,Immunology & Inflammation,NF-kB Signaling Pathway,Neuroscience,Stem Cells,Cardiovascular,Heart,Cardiovascular diseases,Heart disease,INS

    分子量

    11 kDa/21 kDa

    基因ID

    3630

    UniProt

    P01308

    途径

    NF-kappaB Signaling, RTK signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation
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