FFAR1 抗体
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- 抗原 See all FFAR1 抗体
- FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))
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适用
- 人, 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FFAR1 antibody is un-conjugated
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应用范围
- Immunocytochemistry (ICC), Flow Cytometry (FACS)
- 纯化方法
- The splenic lymphocytes from GANP mouse, immunized with the first extracellulardomain peptides of mouse GPR40 conjugated with KLH, were fused to myeloma P3U1cells. The screening of the hybridoma cells was performed on ELISA. The cell line with positive reaction was grown on non-serum medium, from which the antibody waspurified by Protein G affinity chromatography.
- 免疫原
- Partial peptide of Mouse GPR40
- 克隆位点
- G16
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product FFAR1 Primary Antibody
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anti-Free Fatty Acid Receptor 1 (FFAR1) (AA 143-178) antibody
FFAR1 适用: 人 ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (Internal Region) antibodyFFAR1 适用: 人, 猴 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (C-Term) antibodyFFAR1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (AA 121-220) antibodyFFAR1 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (Internal Region) antibodyFFAR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (C-Term) antibodyVerified FFAR1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (N-Term) antibodyFFAR1 适用: 人, 小鼠, 大鼠, 犬, Pig, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (AA 185-234) antibodyFFAR1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (AA 239-300) antibodyFFAR1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Free Fatty Acid Receptor 1 (FFAR1) (3rd Extracellular Loop), (AA 244-259) antibodyFFAR1 适用: 大鼠 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Working dilution For Immunocytochemistry 1.0 ug/ml. For Fluorescence activated cell sorting 0.5 ug/ml
- 限制
- 仅限研究用
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- 浓度
- 0.25 mg/ml
- 缓冲液
- PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)
- 储存液
- ProClin
- 储存条件
- -20 °C
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- 抗原
- FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))
- 别名
- GPR40 (FFAR1 产品)
- 别名
- FFAR1 antibody, GPR40 antibody, FFA1R antibody, GPCR40 antibody, Gpr40 antibody, free fatty acid receptor 1 antibody, FFAR1 antibody, Ffar1 antibody
- 背景
- G protein coupled receptors (GPCRs) are a protein family of transmembrane receptors, and involved in a widevariety of physiological processes. GPR40 is also a member of GPCRs and functions as a receptor for long-chainfree fatty acids (FFA), which is expressed in beta cells in the islets of pancreas and is involved in the regulationof glucose and lipid metabolisms. Long chain FFAs amplify glucose-stimulated insulin secretion from pancreaticbeta cells by activating GPR40.GPR40 knockout mice fed a high-fat diet are protected against obesity-induced hyperinsulinemia and hepaticsteatosis. Transgenic mice overexpressed GPR40 in pancreatic beta cells had impaired beta cell function anddeveloped diabetes.GPR40 is an important mediator of both the acute, stimulatory effects and chronic,deleterious effects of FFAs on beta cells.Moreover, GPR40 may be implicated in the control of breast cancer cell growth by fatty acids and provide a linkbetween fat and cancer.This antibody is specific to GPR40 and will be useful to research for lipid metabolism, obesity and diabetes.
- 途径
- Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Carbohydrate Homeostasis
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