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RAGE 抗体

AGER 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN289974
发货至: 中国
  • 抗原 See all RAGE (AGER) 抗体
    RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
    适用
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    宿主
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    克隆类型
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    多克隆
    标记
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    This RAGE antibody is un-conjugated
    应用范围
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    Western Blotting (WB)
    纯化方法
    This antibody was purified from rabbit serum by Protein G affinity chromatography.
    免疫原
    Partial peptide of Human RAGE
    Top Product
    Discover our top product AGER Primary Antibody
  • 限制
    仅限研究用
  • 浓度
    0.25 mg/ml
    缓冲液
    PBS (containing 2% Block Ace as a stabilizer, 0.1% Proclin as a bacteriostat)
    储存液
    ProClin
    储存条件
    -20 °C
  • 抗原
    RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
    别名
    RAGE (AGER 产品)
    别名
    RAGE antibody, AGER antibody, advanced glycosylation end-product specific receptor antibody, advanced glycosylation end product-specific receptor antibody, MAPK/MAK/MRK overlapping kinase antibody, AGER antibody, Ager antibody, LOC719012 antibody
    背景
    RAGE is the receptor of AGEs, advanced glycation end products with 35,000 molecularweight and was cloned from bovine lung in 1992 ( David Stern et al.,). RAGE has been foundin several tissues such as monocytes, macrophages, endothelial cells, astocytes. The ligand ofRAGE is demonstrated not only AGEs but also anfoterin, EN-RAGE,N-carboxymethyllysine(CML),beta-amyloid and so on. The accumulation of AGEs-proteins invivo has been demonstrated in several disease, it is not clear whether AGEs-proteinsaccumulated in vivo is a direct cause of the disease or rather reflects its effect. Regarding this issue, AGEs-modified proteins are known to interact with several cells by the AGEs-receptors and induce several cellular phenomena. Recently, it has been discovered that RAGE isinvolved in pathophysiological function of diabetes and Alzheimer
    途径
    Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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