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Smooth Muscle Actin 抗体 (N-Term)

Name: Smooth Muscle Actin 抗体 (N-Term)
Brand: antibodies-online
SKU: ABIN2857027
Availability: OutOfStock

KO Validated ACTA2 适用: 人 WB, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

IHC-P Image alpha smooth muscle Actin antibody detects alpha smooth muscle Actin protein at cytoplasm on human liver carcinoma stroma by immunohistochemical analysis. (Smooth Muscle Actin 抗体 (N-Term))

IHC

ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed mouse ESC D3, using alpha Actin (smooth muscle), antibody at 1:200 dilution. (Smooth Muscle Actin 抗体 (N-Term))

IHC-P Image alpha smooth muscle Actin antibody detects alpha smooth muscle Actin protein at cytosol on mouse colon by immunohistochemical analysis. (Smooth Muscle Actin 抗体 (N-Term))

IHC

WB Image alpha smooth muscle Actin antibody detects alpha smooth muscle Actin protein by western blot analysis. (Smooth Muscle Actin 抗体 (N-Term))

IHC-P Image Immunohistochemical analysis of paraffin-embedded U87 xenograft, using alpha Actin (smooth muscle), antibody at 1:500 dilution. (Smooth Muscle Actin 抗体 (N-Term))

IHC

ICC/IF Image Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using alpha Actin (smooth muscle), antibody (Green) at 1:500 dilution. (Smooth Muscle Actin 抗体 (N-Term))

WB Image alpha smooth muscle Actin antibody detects ACTA2 protein by Western blot analysis. (Smooth Muscle Actin 抗体 (N-Term))

Butylidenephthalide reduces EMT-related gene expression in dosage dependent manner in vivo and in cultured HSCs. (Smooth Muscle Actin 抗体 (N-Term))

BMP-7 knock down recovered α-SMA and TGF-β expression. (Smooth Muscle Actin 抗体 (N-Term))

IHC of the expression patterns of (myo)fibroblast, TGFβ1, CTGF, and collagen in human adenomyotic endometrium specimens. (Smooth Muscle Actin 抗体 (N-Term))

IHC

Effect of fasting on renal injury and development of fibrosis after two weeks of unilateral ischemia-reperfusion (IR) injury. (Smooth Muscle Actin 抗体 (N-Term))

14 images

(9 references)

产品编号 ABIN2857027

发货至: 中国

Datasheet as PDF

抗原 See all Smooth Muscle Actin (ACTA2) 抗体

Smooth Muscle Actin (ACTA2) (Actin, alpha 2, Smooth Muscle, Aorta (ACTA2))
抗原表位
48

5

3

2

1

1

1

1

1

1

1

1
N-Term
适用
123

85

78

31

27

26

21

15

14

14

13

13

13

13

10

7

2

1
人
宿主
70

53

1
兔
Compatible Secondaries
克隆类型
79

45
多克隆
标记
65

9

4

3

3

3

3

3

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
This Smooth Muscle Actin antibody is un-conjugated
应用范围
69

54

38

36

28

25

18

14

10

7

5

2

2

2

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, 大鼠, 斑马鱼

产品特性

Rabbit polyclonal antibody to alpha Smooth Muscle Actin
alpha Smooth Muscle Actin antibody

纯化方法

Purified by antigen-affinity chromatography.

质量等级

KO Validated

免疫原

Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human alpha Smooth Muscle Actin. The exact sequence is proprietary.

亚型

IgG

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anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) (N-Term) antibody
ACTA2 适用: 人, 大鼠, 小鼠, Cow WB, IHC, IF, ELISA, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) (N-Term) antibody
Verified ACTA2 适用: 人, 大鼠, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) (N-Term) antibody
ACTA2 适用: 人, 大鼠 IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal 1A4-ACTA2-791 unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) (AA 1-124) antibody
ACTA2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) (AA 2-124) antibody
ACTA2 适用: 人, 大鼠, 小鼠 WB, IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 5C1H11 unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody
ACTA2 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 4A4 unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) (AA 167-377) antibody
ACTA2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody
ACTA2 适用: 人, 大鼠, 小鼠, 小鸡, 兔, 山羊 WB, IHC, ELISA, IHC (p), ICC, IHC (fro), IEM 宿主: 小鼠 Monoclonal alpha-SM1-1A4 unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) (AA 1-377) antibody
ACTA2 适用: 人 WB, IF, ELISA 宿主: 小鼠 Monoclonal 4A8-2H3 unconjugated

anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody
ACTA2 适用: 人, 猴 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 4F4 unconjugated

应用备注

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

说明

Positive Control: Rat2 , C8D30 , NIH-3T3 , C2C12
Validation: KO/KD, Orthogonal

限制

仅限研究用
状态

Liquid

浓度

1.37 mg/mL

缓冲液

1XPBS pH 7, 20 % Glycerol, 0.025 % ProClin 300

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Chang, Hsieh, Lu, Chen, Liang, Lin, Hung, Liou, Wu: "Therapeutic Targeting of Aristolochic Acid Induced Uremic Toxin Retention, SMAD 2/3 and JNK/ERK Pathways in Tubulointerstitial Fibrosis: Nephroprotective Role of Propolis in Chronic Kidney Disease." in: Toxins, Vol. 12, Issue 6, (2020) (PubMed).

Wang, Giusti, Ny, de Witte: "Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid." in: Toxins, Vol. 12, Issue 4, (2020) (PubMed).

Sun, Lei, Huang et al.: "SOX18 Affects Cell Viability, Migration, Invasiveness, and Apoptosis in Hepatocellular Carcinoma (HCC) Cells by Participating in Epithelial-to-Mesenchymal Transition (EMT) Progression and Adenosine ..." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 25, pp. 6244-6254, (2020) (PubMed).

Stone, Stainier: "Paraxial Mesoderm Is the Major Source of Lymphatic Endothelium." in: Developmental cell, Vol. 50, Issue 2, pp. 247-255.e3, (2020) (PubMed).

Yeh, Chen, Liao, Wu, Huang, Lin: "The Bioactive Core and Corona Synergism of Quantized Gold Enables Slowed Inflammation and Increased Tissue Regeneration in Wound Hypoxia." in: International journal of molecular sciences, Vol. 21, Issue 5, (2020) (PubMed).

Cheong, Lai, Wu: "Connective tissue growth factor mediates transforming growth factor β-induced collagen expression in human endometrial stromal cells." in: PLoS ONE, Vol. 14, Issue 1, pp. e0210765, (2019) (PubMed).

Feng, Cheng, Yang, Zhang, Ji, Zhang, Lin, Li, Xiong, Liu, Jiang: "Guidance to rational use of pharmaceuticals in gallbladder sarcomatoid carcinoma using patient-derived cancer cells and whole exome sequencing." in: Oncotarget, Vol. 8, Issue 3, pp. 5349-5360, (2018) (PubMed).

Marro, Pfefferli, de Preux Charles, Bise, Jaźwińska: "Collagen XII Contributes to Epicardial and Connective Tissues in the Zebrafish Heart during Ontogenesis and Regeneration." in: PLoS ONE, Vol. 11, Issue 10, pp. e0165497, (2017) (PubMed).

McCracken, Catá, Crawford, Sinagoga, Schumacher, Rockich, Tsai, Mayhew, Spence, Zavros, Wells: "Modelling human development and disease in pluripotent stem-cell-derived gastric organoids." in: Nature, Vol. 516, Issue 7531, pp. 400-4, (2014) (PubMed).
抗原

Smooth Muscle Actin (ACTA2) (Actin, alpha 2, Smooth Muscle, Aorta (ACTA2))

别名

actin alpha 2, smooth muscle (ACTA2 产品)

别名

AAT6 antibody, ACTSA antibody, MYMY5 antibody, GAMMA-ACTIN antibody, ACT antibody, ACTA3 antibody, ACTE antibody, ACTL3 antibody, ACTSG antibody, Act-4 antibody, Act4 antibody, SMGA antibody, 0610041G09Rik antibody, Actvs antibody, SMalphaA antibody, a-SMA antibody, alphaSMA antibody, wu:fb63d03 antibody, ASMA antibody, SMactin antibody, a-sma antibody, aat6 antibody, actsa antibody, mymy5 antibody, sm-actin antibody, ACTA2 antibody, actc1 antibody, ACT-4 antibody, asma antibody, ACTGE antibody, actin, alpha 2, smooth muscle, aorta antibody, actin, gamma 2, smooth muscle, enteric antibody, actin, alpha 2, smooth muscle, aorta L homeolog antibody, ACTA2 antibody, ACTG2 antibody, Actg2 antibody, Acta2 antibody, acta2 antibody, acta2.L antibody

背景

The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

Cellular Localization: Cytoplasm , cytoskeleton

分子量

42 kDa

基因ID

59

UniProt

P62736

途径

Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development