(3 references)-
- 抗原 See all BRE 抗体
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BRE antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 亚型
- IgG
- Top Product
- Discover our top product BRE Primary Antibody
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anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 51-229) antibody
BRE 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) antibodyKO Validated BRE 适用: 人 WB, IF, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 94-383) antibodyBRE 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (C-Term) antibodyBRE 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 9-338) antibodyBRE 适用: 人, 小鼠 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (AA 1-415) antibodyBRE 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (C-Term) antibodyBRE 适用: 人, 小鼠, 大鼠, 豚鼠, 马, 兔, 斑马鱼, Cow, 犬, 非洲爪蟾, Bat, 小鸡, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE) (N-Term) antibodyBRE 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
- 储存条件
- 4 °C,-20 °C
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: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." in: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).
: "Expression of human BRE in multiple isoforms." in: Biochemical and biophysical research communications, Vol. 288, Issue 3, pp. 535-45, (2001) (PubMed).
: "Identification of a brain- and reproductive-organs-specific gene responsive to DNA damage and retinoic acid." in: Biochemical and biophysical research communications, Vol. 206, Issue 2, pp. 764-74, (1995) (PubMed).
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: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." in: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).
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- 抗原
- BRE (Brain and Reproductive Organ-Expressed (TNFRSF1A Modulator) (BRE))
- 别名
- BRE (BRE 产品)
- 别名
- brcc4 antibody, brcc45 antibody, BRE antibody, LOC100231620 antibody, BRCC4 antibody, BRCC45 antibody, 6030405P19Rik antibody, AI429776 antibody, B830038C02Rik antibody, im:7141046 antibody, zgc:110368 antibody, BRISC and BRCA1 A complex member 2 antibody, brain and reproductive organ-expressed (TNFRSF1A modulator) antibody, BRISC and BRCA1 A complex member 2 L homeolog antibody, babam2 antibody, BABAM2 antibody, Babam2 antibody, BRE antibody, babam2.L antibody
- 背景
- Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti- apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A, however these effects may be indirect.
- 分子量
- 43552 Da
- 基因ID
- 9577
- UniProt
- Q9NXR7
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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