CD137 抗体 (Extracellular Domain)
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北京 101111
Quick Overview for CD137 抗体 (Extracellular Domain) (ABIN2800694)
抗原
See all CD137 (TNFRSF9) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Extracellular Domain
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原理
- Anti-Hu CD137 Purified Low Endotoxin
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交叉反应 （详细）
- Human, Non-Human Primates
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产品特性
- The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
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免疫原
- Recombinant human CD137 ectodomain
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亚型
- IgG1, kappa
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 101-200) antibody
TNFRSF9 适用: 人, 小鼠, 大鼠 ELISA, FACS, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 19-188) antibodyTNFRSF9 适用: 人 ELISA, FACS, WB, IHC, IF, IHC (p), Coat, StM 宿主: 小鼠 Monoclonal 4-1BB-3201 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 214-255) antibodyTNFRSF9 适用: 人 ELISA, FACS, WB 宿主: 小鼠 Monoclonal 2A12C2 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 40-153) antibodyTNFRSF9 适用: 人 FACS, WB 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 150-250) antibodyTNFRSF9 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) antibodyTNFRSF9 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM66 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) antibodyTNFRSF9 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 4G10B9 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (Internal Region) antibodyTNFRSF9 适用: 人, 大鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (Extracellular Domain) antibodyTNFRSF9 适用: 人, Non-Human Primate ELISA, FACS, IP 宿主: 小鼠 Monoclonal 4B4-1 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) antibodyTNFRSF9 适用: 人 FACS, WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Functional application: Inhibition of cytokine production.
Flow cytometry: Recommended dilution: 1-4 μg/mL -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4
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注意事项
- Do not freeze
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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: "Human and mouse CD137 have predominantly different binding CRDs to their respective ligands." in: PLoS ONE, Vol. 9, Issue 1, pp. e86337, (2014) (PubMed).
: "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis." in: Immunology and cell biology, Vol. 90, Issue 4, pp. 449-56, (2012) (PubMed).
: "Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models." in: Journal of molecular recognition : JMR, Vol. 22, Issue 3, pp. 242-9, (2009) (PubMed).
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: "Human and mouse CD137 have predominantly different binding CRDs to their respective ligands." in: PLoS ONE, Vol. 9, Issue 1, pp. e86337, (2014) (PubMed).
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- CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
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别名
- CD137
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背景
- TNF receptor superfamily member 9,CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.,TNFRSF9, 41BB, 4-1BB, MGC2172
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基因ID
- 3604
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UniProt
- Q07011
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途径
- Cancer Immune Checkpoints
抗原
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