CD137 抗体
(3 references)-
- 抗原 See all CD137 (TNFRSF9) 抗体
- CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
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适用
- 人, Non-Human Primate
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CD137 antibody is un-conjugated
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应用范围
- ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func)
- 特异性
- The mouse monoclonal antibody 4B4-1 recognizes an extracellular conformational epitope on CD137, an approximately 40 kDa type I transmembrane protein of the TNFR family expressed mainly on activated T cells.
- 交叉反应 （详细）
- Human, Non-Human Primates
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 内毒素水平
- Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.
- 免疫原
- Recombinant human CD137 ectodomain
- 克隆位点
- 4B4-1
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product TNFRSF9 Primary Antibody
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 101-200) antibody
TNFRSF9 适用: 人, 小鼠, 大鼠 ELISA, FACS, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 19-188) antibodyTNFRSF9 适用: 人 ELISA, FACS, WB, IHC, IF, IHC (p), Coat, StM 宿主: 小鼠 Monoclonal 4-1BB-3201 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) antibodyTNFRSF9 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM66 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 214-255) antibodyTNFRSF9 适用: 人 ELISA, FACS, WB 宿主: 小鼠 Monoclonal 2A12C2 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 40-153) antibodyTNFRSF9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 150-250) antibodyTNFRSF9 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (AA 24-186) antibodyTNFRSF9 适用: 人 ELISA, FACS, WB, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 4G10B9 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) (Internal Region) antibodyTNFRSF9 适用: 人, 大鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) antibodyTNFRSF9 适用: 人, Non-Human Primate ELISA, FACS, IP 宿主: 小鼠 Monoclonal 4B4-1 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9) antibodyTNFRSF9 适用: 人 FACS, WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Functional application: Inhibition of cytokine production.
Flow cytometry: Recommended dilution: 1-4 μg/mL - 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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: "Human and mouse CD137 have predominantly different binding CRDs to their respective ligands." in: PLoS ONE, Vol. 9, Issue 1, pp. e86337, (2014) (PubMed).
: "CD137 differentially regulates innate and adaptive immunity against Mycobacterium tuberculosis." in: Immunology and cell biology, Vol. 90, Issue 4, pp. 449-56, (2012) (PubMed).
: "Epitope mapping of a chimeric CD137 mAb: a necessary step for assessing the biologic relevance of non-human primate models." in: Journal of molecular recognition : JMR, Vol. 22, Issue 3, pp. 242-9, (2009) (PubMed).
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: "Human and mouse CD137 have predominantly different binding CRDs to their respective ligands." in: PLoS ONE, Vol. 9, Issue 1, pp. e86337, (2014) (PubMed).
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- 抗原
- CD137 (TNFRSF9) (Tumor Necrosis Factor Receptor Superfamily, Member 9 (TNFRSF9))
- 别名
- CD137 / 4-1BB (TNFRSF9 产品)
- 别名
- TNFRSF9 antibody, zgc:136557 antibody, 4-1BB antibody, CD137 antibody, CDw137 antibody, ILA antibody, A930040I11Rik antibody, AA408498 antibody, AI325004 antibody, Cd137 antibody, Ly63 antibody, tumor necrosis factor receptor superfamily member 9 antibody, TNF receptor superfamily member 9 antibody, tumor necrosis factor receptor superfamily, member 9a antibody, tumor necrosis factor receptor superfamily, member 9 antibody, TNFRSF9 antibody, tnfrsf9a antibody, Tnfrsf9 antibody
- 背景
- TNF receptor superfamily member 9,CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.,TNFRSF9, 41BB, 4-1BB, MGC2172
- 基因ID
- 3604
- UniProt
- Q07011
- 途径
- Cancer Immune Checkpoints
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