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SET/TAF-I 抗体 (N-Term)

Name: SET/TAF-I 抗体 (N-Term)
SKU: ABIN2798659
Availability: OutOfStock

This anti-SET/TAF-I antibody is a 兔多克隆 antibody detecting SET/TAF-I in WB 和 IHC. Suitable for 人.

产品编号 ABIN2798659

发货至: 中国

Quick Overview for SET/TAF-I 抗体 (N-Term) (ABIN2798659)

抗原

See all SET/TAF-I (SET) 抗体

SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

适用

人

宿主

兔

克隆类型

多克隆

标记

This SET/TAF-I antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product SET Primary Antibody

抗原表位
7

6

6

3

2

2

2

1

1

1

1

1

1

1
AA 47-75, N-Term

原理

Rabbit Anti-Human SET (N-term) Antibody

免疫原

This SET antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-75 amino acids from the N-terminal region of human SET.

亚型

Ig Fraction
anti-SET Nuclear Oncogene (SET) (N-Term) antibody
Verified SET 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 1-277) antibody
SET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人 WB, IHC, IF, IP 宿主: 兔 Monoclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 146-277) antibody
SET 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人, 小鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 1-277) antibody
SET 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal M1-F5 unconjugated

anti-SET Nuclear Oncogene (SET) (N-Term) antibody
SET 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) antibody
SET 适用: 人, 小鼠, 大鼠 WB, FACS, ICC 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 147-235) antibody
SET 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-SET Nuclear Oncogene (SET) (AA 35-84) antibody
SET 适用: 人, 小鼠, 大鼠, 小鸡, 非洲爪蟾, 斑马鱼, Cow, 马, 兔, 豚鼠, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated

应用备注

Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50SET Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/mL

储存条件

4 °C,-20 °C

储存方法

2-8°C (short-term), -20°C (long-term)
抗原

SET/TAF-I (SET) (SET Nuclear Oncogene (SET))

别名

SET

背景

Target Description: Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone binding. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins, however, isoform 2 specific activity is higher.
Gene Symbol: SET

分子量

33489 Da

基因ID

6418

UniProt

Q01105

途径

Apoptosis