BAX 抗体 (AA 41-76)
Quick Overview for BAX 抗体 (AA 41-76) (ABIN2797999)
抗原
See all BAX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 41-76
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原理
- Rabbit Anti-Human Bax (BH3 Domain Specific) Antibody
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免疫原
- This Bax antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 41-76 amino acids from human Bax.
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亚型
- Ig Fraction
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应用备注
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Western Blot, Immunohistochemistry, Flow Cytometry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100, FC: 1:10-50Bax Antibody(BH3) with the Bax gene. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.600 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C (short-term), -20°C (long-term)
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- BAX (BCL2-Associated X Protein (BAX))
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别名
- Bax
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背景
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Target Description: Bax belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bax forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of the Bax gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.
Gene Symbol: BAX
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分子量
- 21184 Da
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基因ID
- 581
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UniProt
- Q07812
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途径
- p53 Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
抗原
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